{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:32:51Z","timestamp":1792740771545,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In a rare disorder such as Huntington's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>), a global network of clinical trial sites with access to patients speeds up recruitment into clinical trials. The objective was to test the hypothesis that demographics, <jats:italic><jats:styled-content style=\"fixed-case\">HTT<\/jats:styled-content><\/jats:italic> genotype, clinical spectrum, and progression are similar in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> participants of two large observational <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> studies, the European Huntington's Disease Network's European <jats:styled-content style=\"fixed-case\">REGISTRY<\/jats:styled-content> study and the North American <jats:styled-content style=\"fixed-case\">COHORT<\/jats:styled-content> study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">REGISTRY<\/jats:styled-content> cross\u2010sectional data were available from a total of 7,384 participants (1,125 [15.2%] premanifest and 6,259 [84.8%] manifest <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">COHORT<\/jats:styled-content> cross\u2010sectional data from 1,499 participants at 44 study sites were available (175 pre\u2010<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> [11.7%], 1,324 manifest <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> [88.3%]). Participants were assessed clinically using the Unified Huntington's Disease Rating Scale (<jats:styled-content style=\"fixed-case\">UHDRS<\/jats:styled-content>). Longitudinal data were available for total motor score and cognitive performance in more than 50% of <jats:styled-content style=\"fixed-case\">REGISTRY<\/jats:styled-content> participants and more than 70% of <jats:styled-content style=\"fixed-case\">COHORT<\/jats:styled-content> participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Demographics, <jats:italic><jats:styled-content style=\"fixed-case\">HTT<\/jats:styled-content><\/jats:italic> genotypes, phenotype, and progression were similar in the two studies. Patients in Europe were prescribed antidyskinetics more frequently, and antidepressants less frequently, than in North America. In either study, participants on antidyskinetic medication had higher <jats:styled-content style=\"fixed-case\">UHDRS<\/jats:styled-content> total motor scores, worse function assessment scores, and worse cognitive scores than those taking antidepressants or no medication. In contrast, motor, function assessment, and cognitive scores were broadly similar in participants taking antidepressants or no medication. The differences in cognitive performances between languages were small.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients, and the way they are assessed, are similar across two continents with different cultures and languages.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12442","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T13:39:50Z","timestamp":1472650790000},"page":"358-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of Huntington's Disease in Europe and North America"],"prefix":"10.1002","volume":"4","author":[{"given":"Michael","family":"Orth","sequence":"first","affiliation":[{"name":"Department of Neurology Ulm University Hospital Ulm 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