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Orthostatic symptoms were reported by 39.6%, male erectile dysfunction by 56.1%, and female anorgasmia by 57.4%. Sialorrhea was an issue in 51.4% of patients, constipation in 43.6%, and dysphagia in 20.1%. Autonomic features increased with higher modified Hoehn and Yahr stages (<jats:italic>P<\/jats:italic> &lt; 0.001). The severity of autonomic dysfunction was associated with the postural instability gait difficulty motor phenotype [\u03b2\u2010coefficient 1.7, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.7, 2.6, <jats:italic>P<\/jats:italic> &lt; 0.001], depression (\u03b2\u2010coefficient 4.1, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.0, 5.2, <jats:italic>P<\/jats:italic> &lt; 0.001), and excess daytime sleepiness (\u03b2\u2010coefficient 3.1, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.9, 4.2, <jats:italic>P<\/jats:italic> &lt; 0.001). Dopamine agonists were the only drug class associated with greater autonomic dysfunction (<jats:italic>P<\/jats:italic> = 0.019). The severity of autonomic dysfunction strongly correlated with the presence of other <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content> (\u03c1 = 0.717, <jats:italic>P<\/jats:italic> &lt; 0.001), and with poorer quality\u2010of\u2010life scores (\u03c1 = 0.483, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Autonomic dysfunction is common in early <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. Autonomic dysfunction correlates with the presence of other <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content>, and with worse quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12454","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T00:50:20Z","timestamp":1476319820000},"page":"509-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Autonomic Dysfunction in Early Parkinson's Disease: Results from the United Kingdom Tracking Parkinson's Study"],"prefix":"10.1002","volume":"4","author":[{"given":"Naveed","family":"Malek","sequence":"first","affiliation":[{"name":"Department of Neurology Ipswich Hospital NHS Trust Ipswich United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Lawton","sequence":"additional","affiliation":[{"name":"School of Social and Community Medicine University of Bristol Bristol 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