{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T11:15:44Z","timestamp":1778411744238,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,20]],"date-time":"2016-11-20T00:00:00Z","timestamp":1479600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Erectile dysfunction (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) is a common nonmotor feature in patients with Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>). Data regarding the tolerability and efficacy of anti\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> medication in the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> population are limited. The aim of this work was to assess the safety and efficacy of sildenafil in treatment of <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> in men with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a double\u2010blind, placebo\u2010controlled, cross\u2010over study consisting of two 4\u2010week arms separated by a 2\u2010week washout period. Treatment sequence (placebo\u2010sildenafil vs. sildenafil\u2010placebo) was randomized. Sildenafil was started at 50 mg and adjusted to 25, 50, or 100 mg after 2 weeks, depending upon side effects. The Erectile Function domain of the International Index of Erectile Function (<jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>; primary outcome measure) and the Parkinson's Disease Quality of Life (secondary outcome measure) were obtained at baseline and end of each treatment period. The <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content> was obtained at each study visit. The difference between group means was tested for statistical significance using <jats:italic>t<\/jats:italic> tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty men participated and completed both treatment arms of the study. There was one instance of headache as a side effect. There was a significant effect of sildenafil on sexual functioning as measured by the <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content> domain (<jats:italic>P<\/jats:italic> &lt; 0.0001; mean for sildenafil = 23.2 \u00b1 7.0; mean for placebo = 12.3 \u00b1 7.5). There were no treatment effects for quality of life (<jats:italic>P<\/jats:italic> = 0.3) or <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> symptoms (<jats:italic>P<\/jats:italic> = 0.86).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sildenafil was safe and improved <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> in this sample of men with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. Overall, <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> symptoms and quality of life were not impacted by use of sildenafil.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12456","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T12:08:19Z","timestamp":1476360499000},"page":"412-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Sildenafil in the Treatment of Erectile Dysfunction in Parkinson's Disease"],"prefix":"10.1002","volume":"4","author":[{"given":"Bryan A.","family":"Bernard","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard Verhagen","family":"Metman","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois 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