{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:57:29Z","timestamp":1776164249235,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["K23NS081087"],"award-info":[{"award-number":["K23NS081087"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Juvenile Huntington's disease (JHD) is a childhood\u2010onset neurodegenerative disorder. Although it is caused by the same pathologic expansion of CGA repeats as adult\u2010onset Huntington's disease, JHD has distinct clinical features. Most clinical research in HD focuses in the adult\u2010onset disease; therefore, little is known about acute care outcomes for patients with JHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Kids' Inpatient Database (KID) was used to examine hospitalizations of children with JHD and to determine the diagnoses and procedures associated with inpatient care for JHD. Regression models were built to examine acute care outcomes, including death, length of stay, and disposition at discharge in patients with JHD compared with patients in the general KID data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of JHD cases among hospitalized children was 1.23 per 100,000 KID inpatient stays. Seizures\/convulsions (58.5%) and psychiatric conditions (26.1%) were the most common primary or secondary diagnoses among JHD patient hospitalizations. The most common procedure was percutaneous endoscopic gastrostomy tube placement (8.6%). Compared with hospitalizations of the general population, hospitalizations of patients with JHD had a lower odds of discharge to home (adjusted odds ratio [AOR], 0.23; 95% confidence interval [CI], 0.14\u20130.37) and an increased likelihood of death (AOR, 8.03; 95% CI, 2.98\u201321.60) or discharge to a short\u2010term care facility (AOR, 4.44; 95% CI, 2.59\u20137.61). A diagnosis of JHD was associated with increased length of stay (7.04 vs. 3.75 days; <jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children with JHD have unique acute care patterns. Future studies are needed to determine the extent to which coordinated care may impact inpatient and disposition needs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12506","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T13:31:53Z","timestamp":1493731913000},"page":"682-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hospitalizations of Children with Huntington's Disease in the United States"],"prefix":"10.1002","volume":"4","author":[{"given":"Adys","family":"Mendizabal","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pennsylvania School of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh\u2010Thu","family":"Ngo Vu","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan","family":"Thibault","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania School of Medicine Philadelphia Pennsylvania"},{"name":"Department of Biostatistics and Epidemiology University of Pennsylvania School of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Gonzalez\u2010Alegre","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania School of Medicine Philadelphia Pennsylvania"},{"name":"The Raymond G. Perelman Center for Cellular and Molecular Therapeutics Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Willis","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania School of Medicine Philadelphia Pennsylvania"},{"name":"Department of Biostatistics and Epidemiology University of Pennsylvania School of Medicine Philadelphia Pennsylvania"},{"name":"Leonard Davis Institute of Health Economics University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/4f8606b742ef3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1963.00460090050005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.6.813"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2310\/7010.2006.00055","article-title":"Clinical characteristics of childhood\u2010onset (juvenile) Huntington disease: report of 12 patients and review of the literature","volume":"21","author":"Gonzalez\u2010Alegre P","year":"2006","journal-title":"J Child Neurol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7461"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20589"},{"key":"e_1_2_7_9_1","unstructured":"Agency for Healthcare Research and Quality. HCUP Kids Inpatient Database. 2014. Available at:https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/kid\/kiddbdocumentation.jsp."},{"key":"e_1_2_7_10_1","first-page":"193","article-title":"The prevalence of Huntington's chorea in South Africa","volume":"58","author":"Hayden MR","year":"1980","journal-title":"S Afr Med J"},{"key":"e_1_2_7_11_1","first-page":"201","article-title":"Chandler JH. Huntington's chorea in Michigan. I. Demography and genetics","volume":"10","author":"Te Reed","year":"1958","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00194305"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.229"},{"key":"e_1_2_7_14_1","unstructured":"Centers for Medicare and Medicaid Services. Eligibility\u2010Medicaid.gov. Available at:https:\/\/www.medicaid.gov\/medicaid-chip-program-information\/by-topics\/eligibility\/eligibility.html"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00633.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.06.013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e3181c1dc56"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01369.x"},{"issue":"6","key":"e_1_2_7_19_1","first-page":"s151","article-title":"Economic burden of multiple sclerosis and the role of managed care organizations in multiple sclerosis management","volume":"22","author":"Owens GM","year":"2016","journal-title":"Am J Manag Care"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20150192"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.01.065"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb05566.x"},{"key":"e_1_2_7_23_1","first-page":"327","article-title":"Unrecognized dementia: sociodemographic correlates","volume":"4","author":"Antonelli Incalzi R","year":"1992","journal-title":"Aging (Milano)"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200210000-00002"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110167"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmdc3.12506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.12506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:27:58Z","timestamp":1760966878000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.12506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/mdc3.12506"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.12506","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"2016-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}