{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T23:33:13Z","timestamp":1772926393434,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/journal\/10.1002\/(ISSN)2330-1619\/homepage\/mdc312512-sup-v002.htm\">View Supplementary Video1<\/jats:ext-link><\/jats:p><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/journal\/10.1002\/(ISSN)2330-1619\/homepage\/mdc312512-sup-v003.htm\">View Supplementary Video2<\/jats:ext-link><\/jats:p><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/journal\/10.1002\/(ISSN)2330-1619\/homepage\/mdc312512-sup-v004.htm\">View Supplementary Video3<\/jats:ext-link><\/jats:p><jats:p>Neurodegeneration with brain iron accumulation (<jats:styled-content style=\"fixed-case\">NBIA<\/jats:styled-content>) includes a rare and heterogeneous group of disorders characterized by iron deposition in the basal ganglia. Pantothenate kinase\u2010associated neurodegeneration (<jats:styled-content style=\"fixed-case\">PKAN<\/jats:styled-content>) is the most common <jats:styled-content style=\"fixed-case\">NBIA<\/jats:styled-content> and has 2 main presentations: typical and atypical, the latter rarely presents with tremor. Our reported patients underwent full neurologic examination, standard brain magnetic imaging, and genetic testing for <jats:styled-content style=\"fixed-case\">PKAN<\/jats:styled-content>. Three patients who had \u201ctremor\u2010dominant\u201d <jats:styled-content style=\"fixed-case\">PKAN<\/jats:styled-content> with a relatively benign course were reported, including 1 with dystonic tremor and 2 with parkinsonian tremor. All 3 patients had homozygous mutations in the <jats:styled-content style=\"fixed-case\">PANK<\/jats:styled-content>2 gene and typical eye of the tiger sign on brain imaging. <jats:styled-content style=\"fixed-case\">PKAN<\/jats:styled-content> (and <jats:styled-content style=\"fixed-case\">NBIA<\/jats:styled-content> in general) may be a potential cause of tremor, thus emphasizing the need to consider this diagnosis even in patients with a clinical diagnosis of essential, dystonic, or parkinsonian tremor.<\/jats:p>","DOI":"10.1002\/mdc3.12512","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T03:53:51Z","timestamp":1495770831000},"page":"772-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tremor\u2010Dominant Pantothenate Kinase\u2010associated Neurodegeneration"],"prefix":"10.1002","volume":"4","author":[{"given":"Mohammad","family":"Rohani","sequence":"first","affiliation":[{"name":"Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease Toronto Western Hospital and Division of Neurology University of Toronto Toronto Ontario Canada"},{"name":"Department of Neurology Hazrat Rasool Hospital Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamali","family":"Shahidi","sequence":"additional","affiliation":[{"name":"Department of Neurology Hazrat Rasool Hospital Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afagh","family":"Alavi","sequence":"additional","affiliation":[{"name":"Genetics Research Center University of Social Welfare and Rehabilitation Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. 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