{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:21:58Z","timestamp":1791332518008,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009575","name":"Jacques und Gloria Gossweiler-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009575","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_155954"],"award-info":[{"award-number":["32003B_155954"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Impaired dexterity is a common symptom in Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) and has been related to limb kinetic apraxia (<jats:styled-content style=\"fixed-case\">LKA<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">LKA<\/jats:styled-content> negatively influenced activities of daily living (<jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. However, the impact on quality of life (QoL) remains to be clarified, which was the aim of the current study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty nondemented patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and 60 age\u2010matched, sex\u2010matched healthy individuals participated in this study. The 39\u2010item Parkinson's Disease Questionnaire was used to measure QoL. Dexterity was assessed by the coin rotation (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) task and the <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content>\u2010related Dexterity Questionnaire 24. Nonmotor symptoms were monitored with part I of the Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale, and motor symptoms were measured with parts <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> of the modified Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regression analysis revealed that dexterity scores controlled for parkinsonian motor symptoms were a strong and independent predictor of QoL in patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study demonstrated that the strong association of impaired dexterity and QoL is independent of bradykinesia, thereby underscoring the clinical relevance of <jats:styled-content 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