{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:41:55Z","timestamp":1790797315389,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health\/National Center for Complementary and Integrative Health (NIH\/NCCIH)","award":["U01AT000613"],"award-info":[{"award-number":["U01AT000613"]}]},{"name":"National Institutes of Health\/National Center for Complementary and Integrative Health (NIH\/NCCIH)","award":["U01AT008197"],"award-info":[{"award-number":["U01AT008197"]}]},{"name":"NIH Office of Dietary Supplements and by the FDA Orphan Products Division","award":["R01FD003359"],"award-info":[{"award-number":["R01FD003359"]}]},{"name":"NIH\/NINDS","award":["P01NS058793"],"award-info":[{"award-number":["P01NS058793"]}]},{"name":"NIH\/NINDS","award":["U01NS071789"],"award-info":[{"award-number":["U01NS071789"]}]},{"name":"NIH\/NINDS","award":["R01NS042861"],"award-info":[{"award-number":["R01NS042861"]}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is increasing evidence that the effects of Huntington's disease (HD) extend beyond the central nervous system. In particular, significant cardiac dysfunction has been described in transgenic mouse models and suggested in symptomatic patients, in whom cardiac involvement could provide an independent risk for sudden cardiac death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Standard 12\u2010lead electrocardiograms (ECGs) obtained at screening from 590 early symptomatic (Stage 1 and 2) HD patients participating in a multi\u2010site Phase III study were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Evaluating only those ECGs in individuals not on medications or with potentially contributing medical conditions, the prevalence of bradycardia was 28.3% (marked in 5.8%), prolonged QRS 4.9%, intraventricular conduction delay 3.4%, right bundle branch block 1.3%, and QTc prolongation 3.7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant cardiac abnormalities, characterized primarily by conduction abnormalities, were found in a larger than expected number of patients. Abnormal intraventricular conduction may lead to increased risk for arrhythmia and may be compounded by prescription of QT\u2010prolonging medications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12596","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T03:46:41Z","timestamp":1517802401000},"page":"306-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Electrocardiogram Abnormalities Suggest Aberrant Cardiac Conduction in Huntington's Disease"],"prefix":"10.1002","volume":"5","author":[{"given":"Christopher D.","family":"Stephen","sequence":"first","affiliation":[{"name":"Departments of Neurology Center for Neuro\u2010imaging of Aging and Neurodegenerative Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Cardiology Center for Neuro\u2010imaging of Aging and Neurodegenerative Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Schifitto","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Hersch","sequence":"additional","affiliation":[{"name":"Departments of Neurology Center for Neuro\u2010imaging of Aging and Neurodegenerative Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Diana","family":"Rosas","sequence":"additional","affiliation":[{"name":"Departments of Neurology Center for Neuro\u2010imaging of Aging and Neurodegenerative Diseases"},{"name":"Center for Neuro\u2010imaging of Aging and Neurodegenerative Diseases"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging"},{"name":"Department of Radiology Massachusetts General Hospital and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70178-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.12.911"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-2012-120004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-130054"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.025577"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.963561"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs291"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(86)80029-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.10.1248"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032426"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmdc3.12596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.12596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:03:51Z","timestamp":1760961831000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.12596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,11]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/mdc3.12596"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.12596","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,11]]},"assertion":[{"value":"2017-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}