{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:45:15Z","timestamp":1790052315904,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Deletion of the short arm of chromosome 18 leads to 18p deletion syndrome. Clinical features include short stature, facial dysmorphism, mental retardation, and several types of movement disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 18p deletion syndrome in our patient was diagnosed using karyotype analysis and confirmed by genome\u2010wide single\u2010nucleotide polymorphism array. We have performed a literature search and summarized all previously reported patients with 18p deletion syndrome and movement disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We present a 41\u2010year\u2010old male patient with childhood\u2010onset generalized dystonia. Dystonia is the most prevalent movement disorder in 18p deletion patients, with onset ranging from childhood to adulthood. Chorea, myoclonus, tremor, tics, and ataxia have been reported in a minority of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dystonia is commonly observed in 18p deletion syndrome. The variable size of the deletion on 18p is probably responsible for the broad phenotypic variability of movement disorders in this syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12707","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T01:48:08Z","timestamp":1541728088000},"page":"70-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Spectrum of Movement Disorders in 18p Deletion Syndrome"],"prefix":"10.1002","volume":"6","author":[{"given":"David","family":"Crosiers","sequence":"first","affiliation":[{"name":"Department of Neurology Antwerp University Hospital  Antwerp Belgium"},{"name":"Center for Molecular Neurology, VIB  Antwerp Belgium"},{"name":"Institute Born\u2010Bunge University of Antwerp  Antwerp Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Blaumeiser","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Antwerp University Hospital  Antwerp Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Van Goethem","sequence":"additional","affiliation":[{"name":"Department of Neurology Antwerp University Hospital  Antwerp Belgium"},{"name":"Center for Molecular Neurology, VIB  Antwerp Belgium"},{"name":"Institute Born\u2010Bunge University of Antwerp  Antwerp Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Antwerp  Antwerp 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