{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:48:34Z","timestamp":1791416914740,"version":"4.3.3"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are currently no proven treatments for fragile X\u2010associated tremor and ataxia syndrome (FXTAS). Validated outcome measures are needed in order to plan and conduct clinical trials to aid in the development of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study examined the reliability and construct validity of the FXTAS Rating Scale. The study was conducted by using ratings from movement disorder specialists, who were blinded to gene status, on the FXTAS Rating Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 295 premutation carriers with and without FXTAS, 33 scale items showed a high level of overall reliability, adequate item\u2010to\u2010total correlations and construct validity. Factor analysis revealed four components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The result demonstrates that many items in the scale meet standard clinimetric criteria, but modification of the scale improved the overall utility.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12708","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T04:17:17Z","timestamp":1542169037000},"page":"120-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinimetric Properties of the Fragile X\u2010associated Tremor Ataxia Syndrome Rating Scale"],"prefix":"10.1002","volume":"6","author":[{"given":"Deborah A.","family":"Hall","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences and Pediatrics Rush University  Chicago Illinois United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn T.","family":"Stebbins","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences and Pediatrics Rush University  Chicago Illinois United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Jacquemont","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Montreal  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Berry\u2010Kravis","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences and Pediatrics Rush University  Chicago Illinois United States"},{"name":"Department of Pediatrics Rush University  Chicago Illinois United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Goetz","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences and Pediatrics Rush University  Chicago Illinois United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi","family":"Hagerman","sequence":"additional","affiliation":[{"name":"MIND Institute and Department of Pediatrics University of California Davis School of Medicine  Sacramento CA United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California Davis School of Medicine  Sacramento CA United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen A.","family":"Leehey","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine  Aurora Colorado United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/374321"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000168900.86323.9c"},{"issue":"10","key":"e_1_2_8_4_1","first-page":"1757","article-title":"Fragile X premutation carriers: characteristic MR imaging findings of adult male patients with progressive cerebellar and cognitive dysfunction","volume":"23","author":"Brunberg JA","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318271f7ff"},{"issue":"16","key":"e_1_2_8_6_1","first-page":"139","article-title":"FMR1 CGG repeat length predicts motor dysfunciton in premutation carriers","volume":"70","author":"Leehey M","year":"2008","journal-title":"Neurology"},{"key":"e_1_2_8_7_1","first-page":"225","volume-title":"Clinical Rating Scale for Tremor","author":"Fahn S","year":"1987"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00231-6"},{"key":"e_1_2_8_9_1","first-page":"153","volume-title":"Recent development in Parkinson's disease","author":"Fahn S","year":"1987"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21252"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"432","article-title":"WEBQUAL: measure of web site quality","volume":"13","author":"Loiacono E","year":"2002","journal-title":"Marketing Educators Conference: Marketing Theory and Applications,"},{"key":"e_1_2_8_13_1","first-page":"1998","volume-title":"Mplus User's Guide","author":"Muthen L"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.6.4.284"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0015825"},{"key":"e_1_2_8_16_1","volume-title":"Data Analysis Using Item Response Theory Methodology: An Introduction to Selected Programs and Applications","author":"Thorpe G","year":"2012"},{"key":"e_1_2_8_17_1","volume-title":"Applications of Item Response Theory to Practical Testing Problems","author":"Lord F","year":"1980"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmdc3.12708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.12708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.12708","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.12708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:16:17Z","timestamp":1760958977000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.12708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,22]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/mdc3.12708"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.12708","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,22]]},"assertion":[{"value":"2018-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}