{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:27:18Z","timestamp":1778660838236,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Droxidopa is approved for adult patients with symptomatic neurogenic orthostatic hypotension (nOH); there is limited information regarding effects on symptoms, outcomes, and quality of life (QOL) beyond two weeks of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Examine the real\u2010world experience of patients taking droxidopa after six months of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This non\u2010interventional, US\u2010based, prospective cohort study utilized a pharmacy hub, identifying patients who recently started droxidopa for nOH treatment. Questionnaires for fall frequency and other patient\u2010reported outcomes (PROs) were completed at baseline and one, three, and six months following droxidopa initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>179 enrolled patients completed baseline surveys. Droxidopa continuation rates were high at months one, three, and six (87%, 79%, and 75%, respectively). From baseline to month one, there was significant reduction in the proportion of patients reporting falling at least once (54.1% vs. 43.0%; <jats:italic>P<\/jats:italic> = 0.0039), with similar observations at month three (52.9% vs. 44.5%; <jats:italic>P<\/jats:italic> = 0.0588) and month six (51.4% vs. 40.0%; <jats:italic>P<\/jats:italic> = 0.0339). Significant improvements from baseline to month one were observed and maintained at months three and six for most PROs, including the Orthostatic Hypotension Symptom Assessment Item 1, Short Falls Efficacy Scale\u2010International, Sheehan Disability Scale, Physical Component of the 8\u2010item Short\u2010Form Health Survey, and Patient Health Questionnaire\u20109.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this non\u2010interventional prospective study, fewer nOH patients reported falling after one, three, and six months of droxidopa treatment. Further, improvements reported in nOH symptoms, physical function, and QOL measures were maintained for six months following treatment initiation. Results from randomized clinical trials are required to validate the findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12726","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T01:50:22Z","timestamp":1546998622000},"page":"235-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Six\u2010Month Use of Droxidopa for Neurogenic Orthostatic Hypotension"],"prefix":"10.1002","volume":"6","author":[{"given":"Cl\u00e9ment","family":"Fran\u00e7ois","sequence":"first","affiliation":[{"name":"Lundbeck  Deerfield IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyndya A.","family":"Shibao","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Italo","family":"Biaggioni","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy M.","family":"Duhig","sequence":"additional","affiliation":[{"name":"Xcenda\u00ae, LLC  Palm Harbor FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"McLeod","sequence":"additional","affiliation":[{"name":"Xcenda\u00ae, LLC  Palm Harbor FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augustina","family":"Ogbonnaya","sequence":"additional","affiliation":[{"name":"Xcenda\u00ae, LLC  Palm Harbor FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apryl","family":"Quillen","sequence":"additional","affiliation":[{"name":"Xcenda\u00ae, LLC  Palm Harbor FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Cannon","sequence":"additional","affiliation":[{"name":"Lundbeck  Deerfield IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron","family":"Padilla","sequence":"additional","affiliation":[{"name":"Lundbeck  Deerfield IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binglin","family":"Yue","sequence":"additional","affiliation":[{"name":"Xcenda\u00ae, LLC  Palm Harbor FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Orloski","sequence":"additional","affiliation":[{"name":"Pharmite  Douglassville PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Kymes","sequence":"additional","affiliation":[{"name":"Lundbeck  Deerfield IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-013-0362-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.805887"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152907780059029"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6736-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-120113"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1123\/japa.2013-0244"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2017.1284668"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp074189"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01512.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-015-0599-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12478"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000615"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-130259"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26086"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000168"},{"key":"e_1_2_8_17_1","unstructured":"IsaacsonS FrancoisC PengG RowseG. 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