{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:14:39Z","timestamp":1787166879357,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015846","name":"Welsh Government","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015846","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Physical activity may be beneficial in Huntington's disease (HD); however, studies to date have been underpowered to detect change. We combined data from five randomized controlled feasibility trials using individual patient data meta\u2010analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Design<\/jats:title>\n                    <jats:p>All trial interventions comprised a combination of supervised and self\u2010directed physical activity, with varied emphasis on aerobic, strength, endurance, flexibility, and task training. Duration ranged from 8 to 16 weeks. The primary outcome was the modified Unified Huntington's Disease Rating Motor Score. Secondary outcomes included the Symbol Digit Modality Test, Berg Balance Scale, 30\u2010second Chair stand, Timed Up and Go, Gait Speed, Physical Performance Test, Six\u2010Minute Walk, International Physical Activity Questionnaire, Hospital Anxiety and Depression Scale, EuroQol Health Utility Index, and Short\u2010Form 36 Health Related Quality of Life Scale. The primary analysis utilized a two\u2010stage approach. A one\u2010stage approach was explored as a sensitivity analysis using a cross\u2010classified (by study site) linear mixed\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred twenty\u2010one participants provided complete data. Risk of bias was moderate; however, primary outcomes were blind assessed. Primary pooled effect estimates adjusted for baseline modified motor score (95% confidence interval) were 0.2 (\u20132.1 to 2.6) favoring control. There was considerable heterogeneity between the studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was no evidence of an exercise effect on the modified motor score in these relatively short\u2010duration interventions. Longer\u2010duration trials incorporating supervised components meeting frequency, intensity, time, and type principles are required. Lack of common outcomes limited the analysis and highlight the importance of a core outcome set for evaluating exercise in HD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.12809","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T05:42:05Z","timestamp":1561614125000},"page":"567-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Exercise Interventions in Huntington's Disease: An Individual Patient Data Meta\u2010Analysis"],"prefix":"10.1002","volume":"6","author":[{"given":"Rebecca","family":"Playle","sequence":"first","affiliation":[{"name":"Centre for Trials Research Cardiff University  Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polyxeni","family":"Dimitropoulou","sequence":"additional","affiliation":[{"name":"Centre for Trials Research Cardiff University  Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kelson","sequence":"additional","affiliation":[{"name":"School of Mathematics\/The Alan Turing Institute University of Exeter  Exeter United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Quinn","sequence":"additional","affiliation":[{"name":"Centre for Trials Research Cardiff University  Cardiff United Kingdom"},{"name":"Teachers College Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-5909","authenticated-orcid":false,"given":"Monica","family":"Busse","sequence":"additional","affiliation":[{"name":"Centre for Trials Research Cardiff University  Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60111-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1056"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-170260"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8310-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215507075495"},{"key":"e_1_2_8_7_1","article-title":"Effects of a one year intensive multidisciplinary rehabilitation program for patients with Huntington's disease: a prospective intervention study","volume":"5","author":"Piira A","year":"2013","journal-title":"PLoS Curr"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12053"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.hd.2c56ceef7f9f8e239a59ecf2d94cddac"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.312"},{"key":"e_1_2_8_11_1","first-page":"189","article-title":"Effectiveness of intensive neurorehabilitation in patients with Huntington's disease","volume":"49","author":"Ciancarelli I","year":"2013","journal-title":"Eur J Phys Rehabil Med"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-14-395"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/NPT.0000000000000016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.06.023"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzx031"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215512473762"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20140123"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c221"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7171"},{"key":"e_1_2_8_20_1","unstructured":"HigginsJPT GreenS eds.Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration 2011. Available fromhttp:\/\/handbook.cochrane.org. Accessed 1 August 2018."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/met0000043"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.5334\/tohm.515","article-title":"Exercise in Huntington's disease: current state and clinical significance","volume":"9","author":"Mueller SM","year":"2019","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004743"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmdc3.12809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.12809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.12809","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.12809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:31:04Z","timestamp":1760963464000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.12809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,18]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/mdc3.12809"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.12809","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,18]]},"assertion":[{"value":"2018-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}