{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:45:31Z","timestamp":1761007531921,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We describe the clinical and neuropathological features of a patient with T\u2010cell\u2010mediated paraneoplastic limbic encephalitis, parkinsonism, hypothermia, and narcolepsy\u2010like presentation associated with endometrial carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This patient with prominent parkinsonism and narcolepsy broadens the phenotype of known paraneoplastic syndromes and demonstrates the importance of investigation for occult malignancy even in the absence of paraneoplastic antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case report with diagnosis confirmed at postmortem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Paraneoplastic antibodies were not detected. The initial improvement with immunosuppression was short lived, and postmortem neuropathological examination demonstrated encephalitis with predominant T\u2010cell infiltration affecting the hypothalamus and extending to the brainstem, suggestive of a paraneoplastic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the possibility of a novel antibody cannot be ruled out, consideration must also be given to recent demonstration of purely T\u2010cell\u2010mediated neuronal destruction in the context of paraneoplastic syndromes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.12883","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T00:24:27Z","timestamp":1576283067000},"page":"223-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibody\u2010Negative Paraneoplastic Limbic Encephalitis, Parkinsonism, Hypothermia, and Narcolepsy Associated with Endometrial Carcinoma"],"prefix":"10.1002","volume":"7","author":[{"given":"Declan","family":"Brennan","sequence":"first","affiliation":[{"name":"Centre for Brain Health Dublin Neurological Institute at the Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olwen C.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Centre for Brain Health Dublin Neurological Institute at the Mater Misericordiae University Hospital  Dublin Ireland"},{"name":"Division of Neuroimmunology Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor","family":"Fearon","sequence":"additional","affiliation":[{"name":"Centre for Brain Health Dublin Neurological Institute at the Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Brett","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Beaumount Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Murray","sequence":"additional","affiliation":[{"name":"Centre for Brain Health Dublin Neurological Institute at the Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Lynch","sequence":"additional","affiliation":[{"name":"Centre for Brain Health Dublin Neurological Institute at the Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00652"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0099"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.034447"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70060-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.56"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.209"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816721"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05453"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh203"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12370"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.01.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.12.2253"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.10.1553"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh203"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5414\/NP300754"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318211c379"},{"issue":"5","key":"e_1_2_8_18_1","first-page":"385","article-title":"IgLON 5antibody. 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