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The imaging results showed a middle cerebellar peduncles sign in only 6 patients; another symptom included high\u2010signal intensity in the splenium of the corpus callosum, and diffuse cerebral deep white matter changes (e.g., in the pons) are more common. The rate of psychiatric disorders, especially depression, is higher than in the general population. There is a clear impairment in executive functioning and fine motor skills in connection with a higher FXTAS stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The manifestation of FXTAS symptoms in female carriers can be diverse with a milder phenotype and a lower penetrance than those observed in male premutation carriers. The middle cerebellar peduncles sign is present in only a small percentage of the sample, and we propose that the imaging criteria for FXTAS in women need to be expanded.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13084","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T04:29:43Z","timestamp":1598848183000},"page":"910-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Women with Fragile X\u2013associated Tremor\/Ataxia Syndrome"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-7244","authenticated-orcid":false,"given":"Andrea","family":"Schneider","sequence":"first","affiliation":[{"name":"Medical Investigation of Neurodevelopmental Disorders Institute  Sacramento California USA"},{"name":"Department of Pediatrics, School of Medicine University of California\u2013Davis, Medical Center  Sacramento California 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