{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:32:39Z","timestamp":1788481959244,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 RR024150"],"award-info":[{"award-number":["UL1 RR024150"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P50 AG016574"],"award-info":[{"award-number":["P50 AG016574"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rapid eye movement (REM) sleep behavior disorder (RBD) occurs occasionally in essential tremor (ET), but polysomnographic REM sleep without atonia (RSWA) analyses have been sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the amount and distribution of polysomnographic RSWA, the electrophysiologic substrate of RBD, in patients with Parkinson's disease (PD) and ET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed quantitative RSWA in 73 patients: PD (23), ET (23), and age\u2010sex\u2010matched controls (27). None had dream\u2010enactment behavior history or received antidepressants. Phasic, tonic, \u201cany,\u201d and phasic\u2010burst duration RSWA measures were calculated in the submentalis (SM) and anterior tibialis (AT) muscles. The automated REM atonia index (RAI) was also determined. Statistical analysis was performed by Kruskal\u2010Wallis rank\u2010sum and Mann\u2010Whitney tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SM phasic RSWA was significantly greater for PD than ET patients and controls (12.5%\u2009\u00b1\u200912.8% vs. 4.9%\u2009\u00b1\u20096.7%, 3.9%\u2009\u00b1\u20092.6%), as was SM \u201cany\u201d (13.54%\u2009\u00b1\u200914.30% vs. 5.2%\u2009\u00b1\u20097.6%, 4.2%\u2009\u00b1\u20092.6%). RAI was significantly lower in PD than in ET and controls (0.78\u2009\u00b1\u20090.23 vs. 0.92\u2009\u00b1\u20090.09 vs. 0.90\u2009\u00b1\u20090.17, <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.005), but no different between ET and controls. AT phasic and \u201cany\u201d RSWA was similar between the 3 groups. ET and control RSWA was similar in all measures. Two ET patients (8.7%) had SM RSWA similar to PD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated SM RSWA distinguished PD from ET in patients without dream\u2010enactment symptoms and occurs frequently in PD patients, and in isolated tremor suggests underlying synucleinopathy. Prospective studies will further validate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13112","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T01:32:29Z","timestamp":1604280749000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Quantitative <scp>REM<\/scp> Sleep without Atonia in Parkinson's Disease and Essential Tremor"],"prefix":"10.1002","volume":"8","author":[{"given":"Thomas R.","family":"Gossard","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Mayo Center for Sleep Medicine  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8158-8835","authenticated-orcid":false,"given":"Stuart J.","family":"McCarter","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Mayo Center for Sleep Medicine  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