{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:43:46Z","timestamp":1761864226529,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have suggested that cognitive processing speed may be useful for assessing early cognitive change in premanifest Huntington's disease (HD); however, current measures lack the ability to control for the effects of motor dysfunction commonly found in HD. The Computerized Test of Information Processing (CTiP) is a rapidly administered computerized tool that allows for the examination of central cognitive processing speed by using motor\u2010corrected scores to account for motor dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine central cognitive processing speed as an early marker of HD onset using the CTiP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The CTiP and other measures were administered to 102 HD gene carriers and 55 healthy adults (HA). Gene carriers included presymptomatic HD (pre\u2010HD; n = 33), prodromal HD (pro\u2010HD; ie, individuals close to disease onset; n = 23), and mild\u2013moderate HD (HD; n = 46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HD group performed significantly slower than all other groups (HA, pre\u2010HD, and pro\u2010HD) on most subtests (<jats:italic>P<\/jats:italic>s\u2009&lt;\u2009.05). Moreover, the pro\u2010HD group performed significantly slower than the HA group on both motor\u2010corrected subtests (<jats:italic>P<\/jats:italic>s\u2009&lt;\u20090.05). Effect sizes associated with significant group differences between the pro\u2010HD and HA groups on motor\u2010corrected CTiP subtests (<jats:italic>d<\/jats:italic> = 0.73 and 0.84) were similar to effect sizes associated with group differences on the Symbol Digit Modalities Test (<jats:italic>d<\/jats:italic> = .82) and other traditional cognitive assessments (Montreal Cognitive Assessment, <jats:italic>d<\/jats:italic> = .75; Mini\u2010Mental State Examination, <jats:italic>d<\/jats:italic> = .84).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CTiP may be a useful marker of deficits in central cognitive processing speed in individuals close to manifest onset of HD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13121","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T01:10:53Z","timestamp":1606093853000},"page":"100-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Central Cognitive Processing Speed Is an Early Marker of Huntington's Disease Onset"],"prefix":"10.1002","volume":"8","author":[{"given":"Jody","family":"Corey\u2010Bloom","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of California San Diego  San Diego California USA"},{"name":"Department of Psychology San Diego State University\/University of California San Diego Joint Doctoral Program in Clinical Psychology  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"McKenna E.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilex","family":"Beltran\u2010Najera","sequence":"additional","affiliation":[{"name":"Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea I.","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chase M.","family":"Snell","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Castleton","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haileigh","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenton","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Psychology San Diego State University\/University of California San Diego Joint Doctoral Program in Clinical Psychology  San Diego California USA"},{"name":"Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"Huntington Study Group. 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