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The Hoehn and Yahr staging system (HY), Clinical Impression of Severity Index for PD (CISI\u2010PD), MDS\u2010NMS (including NMF\u2010 subscale), Non\u2010Motor Symptoms scale (NMSS), and MDS\u2010Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS) were applied. A NMS was considered present when scored \u22651. Differences in scores by sex and HY, CISI\u2010PD, and MDS\u2010UPDRS severity levels were calculated using Fisher's exact and chi\u2010squared tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using the MDS\u2010NMS, NMS were present in 99.7% of patients and the mean number of NMS was 16.13 (SD: 9.36). The most prevalent NMS was muscle, joint or back pain (67.4% of the sample) and the least prevalent was dopamine dysregulation syndrome (2.2%). Feeling sad or depressed was significantly more prevalent in women. Using the MDS\u2010NMS revealed more NMS than the other scales assessing NMS. NMF were present in 41% of the sample, with fatigue being the most prevalent symptom (68.5% patients with NMF), and no differences by sex. Patients with greater PD severity had higher prevalence of NMS than patients with lower severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Almost all patients with PD experience NMS, and many experience NMF. Prevalence rates for NMS using the MDS\u2010NMS are higher than on other scales used and increase with higher disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.13122","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T15:40:39Z","timestamp":1606146039000},"page":"231-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Prevalence of Non\u2010Motor Symptoms and Non\u2010Motor Fluctuations in Parkinson's Disease Using the\n                    <scp>MDS\u2010NMS<\/scp>"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-0675","authenticated-orcid":false,"given":"Carmen","family":"Rodriguez\u2010Blazquez","sequence":"first","affiliation":[{"name":"National Centre of Epidemiology Carlos III Institute of Health  Madrid Spain"},{"name":"Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED) Carlos III Institute of Health  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9872-6680","authenticated-orcid":false,"given":"Anette","family":"Schrag","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rizos","sequence":"additional","affiliation":[{"name":"King's College London, Department of Neurosciences, Institute of Psychiatry, Psychology &amp; Neuroscience and Parkinson's Foundation Centre of Excellence King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-0505","authenticated-orcid":false,"given":"K. Ray","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"King's College London, Department of Neurosciences, Institute of Psychiatry, Psychology &amp; Neuroscience and Parkinson's Foundation Centre of Excellence King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-5280","authenticated-orcid":false,"given":"Pablo","family":"Martinez\u2010Martin","sequence":"additional","affiliation":[{"name":"Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED) Carlos III Institute of Health  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-7168","authenticated-orcid":false,"given":"Daniel","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia Department of Veterans Affairs 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