{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:51:40Z","timestamp":1778885500398,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuropsychiatric symptoms in Parkinson's disease (PD) may increase dementia (PDD) risk. The predictive value of these symptoms, however, has not been compared to clinical and demographic predictors of future PDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Determine if neuropsychiatric symptoms are useful markers of PDD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>328 PD participants completed baseline neuropsychiatric and MDS\u2010Task Force\u2010Level II assessments. Of these, 202 non\u2010demented individuals were followed\u2010up over a four\u2010years period to detect conversion to PDD; 51 developed PDD. ROC analysis tested associations between baseline neuropsychiatric symptoms and future PDD. The probability of developing PDD was also modeled as a function of neuropsychiatric inventory (NPI)\u2010total score, PD Questionnaire (PDQ)\u2010hallucinations, PDQ\u2010anxiety, and contrasted to cognitive ability, age, and motor function. Leave\u2010one\u2010out information criterion was used to evaluate which models provided useful information when predicting future PDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PDD group experienced greater levels of neuropsychiatric symptoms compared to the non\u2010PDD groups at baseline. Few differences were found between the PD\u2010MCI and PD\u2010N groups. Six neuropsychiatric measures were significantly, but weakly, associated with future PDD. The strongest was NPI\u2010total score: AUC = 0.66 [0.57\u20130.75]. There was, however, no evidence it contained useful out\u2010of\u2010sample predictive information of future PDD (delta ELPD = 1.8 (SD 2.5)); Similar results held for PDQ\u2010hallucinations and PDQ\u2010anxiety. In contrast, cognitive ability (delta ELPD = 36 (SD 8)) and age (delta ELPD = 11 (SD 5)) provided useful predictive information of future PDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cognitive ability and age strongly out\u2010performed neuropsychiatric measures as markers of developing PDD within 4\u2009years. Therefore, neuropsychiatric symptoms do not appear to be useful markers of PDD risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.13151","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T12:44:37Z","timestamp":1611060277000},"page":"390-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neuropsychiatric Symptoms Are Associated with Dementia in Parkinson's Disease but Not Predictive of it"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6634-8622","authenticated-orcid":false,"given":"Kyla\u2010Louise","family":"Horne","sequence":"first","affiliation":[{"name":"New Zealand Brain Research Institute  Christchurch New Zealand"},{"name":"Department of Medicine University of Otago  Christchurch New Zealand"},{"name":"Brain Research New Zealand Rangahau Roro Aotearoa Centre of Research Excellence  Christchurch New 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