{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:34:53Z","timestamp":1790793293151,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013327","name":"H. Lundbeck A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rapid eye movement (REM) sleep behavior disorder (RBD) is associated with neurodegenerative diseases; however, few longitudinal studies assess the individual evolution of RBD and REM sleep without atonia (RWA) in Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to evaluate RBD and RWA changes over time as well as potentially influential factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>RBD and RWA were analyzed using video\u2010supported polysomnography (vPSG) in initially de novo PD patients at baseline and every 2\u2009years for a total of 6\u2009years. The influence of time, age, sex, levodopa equivalent daily dose (LEDD), unified Parkinson's disease rating scale (UPDRS) sum scores, benzodiazepine intake, Mini\u2010Mental State Examination (MMSE) total scores, and dyskinesia on RWA were investigated using mixed\u2010effect models to account for intra\u2010individual correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 6\u2009years, vPSG data were available from 98 of the initial 159 de novo PD patients. RBD prevalence increased from 25% at baseline to 52%. Of the 31 PD patients with RBD and valid vPSGs at all time\u2010points, RWA increased from an average of 19% at baseline to 41% at 6\u2010year follow\u2010up modeled to grow by 29.7% every 2\u2009years (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Time was an independent factor (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) for RWA increase. Age was an independent factor influencing RWA increase (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04). Sex, LEDD, UPDRS sum scores, benzodiazepines, MMSE total scores, and dyskinesia did not have any significant influence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RBD and RWA increased significantly over time in PD; time and age were independent factors in a prospective cohort. RBD and RWA can be considered PD progression markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.13168","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T01:30:57Z","timestamp":1613352657000},"page":"534-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Incidence and Progression of Rapid Eye Movement Behavior Disorder in Early Parkinson's Disease"],"prefix":"10.1002","volume":"8","author":[{"given":"Larissa","family":"Zimansky","sequence":"first","affiliation":[{"name":"Department of Neurosurgery University Medical Center  G\u00f6ttingen Germany"},{"name":"Paracelsus\u2010Elena Klinik  Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Lucia","family":"Muntean","sequence":"additional","affiliation":[{"name":"Paracelsus\u2010Elena Klinik  Kassel 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