{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:41:57Z","timestamp":1790790117780,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Identifying sex\u2010related differences is critical for enhancing our understanding of factors that may impact prognosis and advance treatments in Huntington's disease (HD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate if sex\u2010related differences exist in clinical HD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Longitudinal study of the Enroll\u2010HD database. Manifest HD patients were included in the analysis (N = 8401). Linear mixed models were used to assess motor, behavioral, and cognitive functioning over a series of four annual visits, and compared male and female HD gene carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HD patients showed significant sex\u2010dependent differences in motor, cognitive, and behavioral symptoms. Both sexes had worsened motor symptoms over the course of four visits, but there was a significant disparity between sexes, with females consistently presenting with more symptoms than males. For behavioral symptoms, specifically depressive symptoms, females had significantly more depressive symptoms, although self\u2010reported symptoms in both sexes became less severe throughout time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our analyses suggest that women have worse symptoms than men during the course of HD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13178","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T02:37:22Z","timestamp":1613961442000},"page":"420-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Sex Differences in Huntington's Disease: Evaluating the <scp>Enroll\u2010HD<\/scp> Database"],"prefix":"10.1002","volume":"8","author":[{"given":"Samantha","family":"Hentosh","sequence":"first","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center (UTHealth)  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine McGovern Medical School, The University of Texas Health Science Center (UTHealth)  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Patino","sequence":"additional","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center (UTHealth)  Houston Texas USA"},{"name":"HDSA Center of Excellence at UTHealth  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Weldon","family":"Furr","sequence":"additional","affiliation":[{"name":"School of Medicine, Louisiana State University Health Sciences Center Shreveport  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia P.","family":"Rocha","sequence":"additional","affiliation":[{"name":"The Mitchell Center for Alzheimer's disease and Related Brain Disorders, Department of Neurology McGovern Medical School, The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Furr Stimming","sequence":"additional","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center (UTHealth)  Houston Texas USA"},{"name":"HDSA Center of Excellence at UTHealth  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.24"},{"issue":"6","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/brainsci7060067","article-title":"Neuropsychiatric burden in Huntington's disease","volume":"7","author":"Paoli RA","year":"2017","journal-title":"Brain Sci"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27653"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0294-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.04.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2011.04.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.050930"},{"key":"e_1_2_8_9_1","unstructured":"CHDI Foundation.A user guide to the clinical datasets and biosamples available from Enroll\u2010HD. 2018. p. 1\u20108."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12097"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.235241"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.09.012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.05.026"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.01.006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.2.452"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2015.11.003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.11.45"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.17.4.496"},{"key":"e_1_2_8_19_1","first-page":"147","volume-title":"Anosognosia in Huntington's Disease","author":"Tranel D","year":"2010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008906"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.1.52"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-170270"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.13178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.13178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.13178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:19:07Z","timestamp":1760955547000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.13178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/mdc3.13178"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.13178","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,8]]},"assertion":[{"value":"2020-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}