{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:52:19Z","timestamp":1786632739933,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease with orthostatic hypotension (PD\u2009+\u2009OH) can be difficult to distinguish clinically from the parkinsonian form of multiple system atrophy (MSA\u2010P). Previous studies examined cardiac sympathetic neuroimaging to differentiate PD from MSA but without focusing specifically on PD\u2009+\u2009OH versus MSA\u2010P, which often is the relevant differential diagnostic issue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate the utility of cardiac sympathetic neuroimaging by\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010dopamine positron emission tomographic (PET) scanning for separating PD\u2009+\u2009OH from MSA\u2010P.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cardiac\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010dopamine PET data were analyzed from 50 PD\u2009+\u2009OH and 68 MSA\u2010P patients evaluated at the NIH Clinical Center from 1990 to 2020. Noradrenergic deficiency was defined by interventricular septal\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010dopamine\u2010derived radioactivity &lt;6000 nCi\u2010kg\/cc\u2010mCi in the 5\u2032 frame with mid\u2010point 8\u2032 after initiation of 3\u2032 tracer injection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010Dopamine PET separated the PD\u2009+\u2009OH from the MSA\u2010P group with a sensitivity of 92% and specificity of 96%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Cardiac\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010dopamine PET scanning efficiently distinguishes PD\u2009+\u2009OH from MSA\u2010P.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.13190","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T04:41:47Z","timestamp":1615437707000},"page":"582-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cardiac\n                    <scp>\n                      <sup>18<\/sup>\n                      F\u2010Dopamine PET\n                    <\/scp>\n                    Distinguishes\n                    <scp>PD<\/scp>\n                    with Orthostatic Hypotension from Parkinsonian\n                    <scp>MSA<\/scp>"],"prefix":"10.1002","volume":"8","author":[{"given":"Abhishek","family":"Lenka","sequence":"first","affiliation":[{"name":"Department of Neurology Medstar Georgetown University Hospital  Washington, DC USA"},{"name":"Autonomic Medicine Section, National 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