{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:48:55Z","timestamp":1770022135044,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pimavanserin is a serotonin 2A receptor inverse agonist and antagonist used for the treatment of hallucinations and delusions in Parkinson's disease psychosis. Numerous studies support a modulatory role of serotonin in Tourette syndrome (TS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether or not pimavanserin affects TS symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this open\u2010label study of TS adult patients, pimavanserin was titrated to 34\u2009mg\/day over 1\u2009week and continued for an additional 7\u2009weeks followed by a 2\u2010week washout. Tic severity, the primary outcome measure, was assessed by the Yale Global Tic Severity Scale Total Tic Severity score (YGTSS\u2010TTS). Secondary outcome measures included changes in the Yale\u2010Brown Obsessive Compulsive Scale (Y\u2010BOCS), the Tourette Syndrome Clinical Global Impression of Change (TS\u2010CGIC), the Tourette Syndrome\u2010Patient Global Impression of Impact (TS\u2010PGII), and the Gilles de la Tourette Syndrome \u2013 Quality of Life scale (GTS\u2010QOL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 12 patients, but 2 dropped out after week 2 due to non\u2010serious side effects. In the 10 patients, mean (standard deviation (SD)) age 34 (12.9) who completed the study the mean (SD) baseline YGTSS\u2010TTS was 34 (9.3). This decreased by 3.6 (4.9) points at week 8, a 12% reduction in tic severity (<jats:italic>P<\/jats:italic>\u00a0=\u20090.03). This improvement is small and may not be clinically important. Significant improvement was noted in the TS\u2010CGIC, TS\u2010PGII and GTS\u2010QO. No serious adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study suggest that pimavanserin is safe and associated with improvement in motor and non\u2010motor TS symptoms. These findings warrant further study by a larger, placebo\u2010controlled, trial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13207","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T02:07:34Z","timestamp":1617242854000},"page":"694-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pilot Study to Evaluate Pimavanserin for the Treatment of Motor and Behavioral Symptoms of Tourette Syndrome"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-7771","authenticated-orcid":false,"given":"Andrew","family":"Billnitzer","sequence":"first","affiliation":[{"name":"Department of Neurology Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Jankovic","sequence":"additional","affiliation":[{"name":"Department of 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