{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T01:29:45Z","timestamp":1775352585018,"version":"3.50.1"},"reference-count":89,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) are being widely documented. However, movement disorders in the setting of 2019 coronavirus infectious disease (COVID\u201019) have been a strikingly less discussed topic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To summarize available pieces of evidence documenting de novo movement disorders in COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the existing PRISMA consensus statement. Data were collected from PubMed, EMBASE, Web of Science, and Scopus databases up to the 29th January, 2021, using pre\u2010specified searching strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two articles were selected for the qualitative synthesis. Among these, a total of 52 patients with de novo movement disorders were reported. Most of these had myoclonus, ataxia, tremor or a combination of these, while three had parkinsonism and one a functional disorder. In general, they were managed successfully by intravenous immunoglobulin or steroids. Some cases, primarily with myoclonus, could be ascribed to medication exposures, metabolic disturbances or severe hypoxia, meanwhile others to a post\u2010or para\u2010infectious immune\u2010mediated mechanism. SARS\u2010CoV\u20102 could also invade the central nervous system, through vascular or retrograde axonal pathways, and cause movement disorders by two primary mechanisms. Firstly, through the downregulation of angiotensin\u2010converting enzyme 2 receptors, resulting in the imbalance of dopamine and norepinephrine; and secondly, the virus could cause cellular vacuolation, demyelination and gliosis, leading to encephalitis and associated movement disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>De novo movement disorders are scantly reported in COVID\u201019. The links between SARS\u2010CoV\u20102 and movement disorders are not yet established. However, we should closely monitor COVID\u201019 survivors for the possibility of post\u2010COVID movement disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13224","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T11:46:43Z","timestamp":1618573603000},"page":"669-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["De Novo Movement Disorders and <scp>COVID<\/scp>\u201019: Exploring the Interface"],"prefix":"10.1002","volume":"8","author":[{"given":"Ritwik","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of General Medicine Burdwan Medical College &amp; Hospital  Burdwan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uttam","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of General Medicine Burdwan Medical College &amp; Hospital  Burdwan 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