{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:46:56Z","timestamp":1790293616297,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>\u201cOndine's curse\u201d or central hypoventilation, induces an apparently spontaneous failure of automatic respiratory drive, henceforth necessitating a conscious effort to breathe and sleep induced hypoventilation. It is typically seen in congenital central hypoventilation syndrome, but may be acquired.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To highlight Ondine's curse as part of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP\u201017) secondary to microtubule associated protein tau (<jats:italic>MAPT<\/jats:italic>) variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe the clinical and neuropathological findings in two patients with fatal Ondine's curse associated with FTDP\u201017 and secondary to <jats:italic>MAPT<\/jats:italic> variants (FTDP\u201017t). We discuss neuroanatomical correlates. We review two prior reports of central hypoventilation associated with <jats:italic>MAPT<\/jats:italic> variants suggesting that Ondine's curse occurs uncommonly in FTDP\u201017t.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite variants affecting different regions of <jats:italic>MAPT<\/jats:italic> and a degree of heterogeneity in pathological findings, the patients reviewed all experienced central hypoventilation during their disease course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tauopathy should be considered in patients with adult\u2010onset Ondine's curse.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13265","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T11:26:38Z","timestamp":1623929198000},"page":"954-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ondine's Curse in Frontotemporal Dementia with Parkinsonism Linked to Chromosome 17 Caused by <scp><i>MAPT<\/i><\/scp> Variants"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-2960","authenticated-orcid":false,"given":"Laura","family":"Williams","sequence":"first","affiliation":[{"name":"Dublin Neurological Institute, Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-8834","authenticated-orcid":false,"given":"Diana A.","family":"Olszewska","sequence":"additional","affiliation":[{"name":"Dublin Neurological Institute, Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Fearon","sequence":"additional","affiliation":[{"name":"Dublin Neurological Institute, Mater Misericordiae University Hospital  Dublin 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