{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:10:40Z","timestamp":1768284640403,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The coronavirus disease 2019 (COVID\u201019) pandemic has caused worse health outcomes among elderly populations with specific pre\u2010existing medical conditions and chronic illnesses. There are limited data on health outcomes of hospitalized Parkinson's disease (PD) individuals infected with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine clinical characteristics and outcomes in hospitalized PD individuals infected with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals admitted to NewYork\u2010Presbyterian with a diagnosis of PD were retrospectively identified using an electronic medical record system. Clinical characteristics and mortality were abstracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five individuals with PD, mostly male (76%) with a median age of 82\u2009years (IQR 73\u201388\u2009years), were hospitalized for COVID\u201019 infection. A total of 80% of individuals had mid\u2010stage to advanced PD (Hoehn and Yahr 3\u20135) and 80% were on symptomatic pharmacologic therapy, most commonly levodopa (72%). The most common comorbidities were hypertension (72%) and mild cognitive impairment or dementia (48%). A total of 44% and 12% of individuals presented with altered mental status and falls, respectively. Mortality rate was 32% compared to 26% for age\u2010matched controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.743). Individuals who died were more likely to have encephalopathy during their admission (88% vs. 35%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PD individuals who require hospitalization for COVID\u201019 infection are likely to be elderly, have mid\u2010stage to advanced disease, and be on pharmacologic therapy. Hypertension and cognitive impairment are common comorbidities in these individuals and encephalopathy during hospitalization is associated with risk of death. Altered mental status and falls are clinical presentations of COVID\u201019 infection in PD that clinicians should be aware of. A diagnosis of PD is not a risk factor for COVID\u201019 mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13309","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:58:13Z","timestamp":1626051493000},"page":"1100-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Characteristics and Outcomes of Parkinson's Disease Individuals Hospitalized with <scp>COVID<\/scp>\u201019 in a New York City Hospital System"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5289-6174","authenticated-orcid":false,"given":"Lynda","family":"Nwabuobi","sequence":"first","affiliation":[{"name":"Division of Neurodegenerative Diseases, Parkinson's Disease and Movement Disorders Institute, Department of Neurology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cenai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Henchcliffe","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiral","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harini","family":"Sarva","sequence":"additional","affiliation":[{"name":"Division of Neurodegenerative Diseases, Parkinson's Disease and Movement Disorders Institute, Department of Neurology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-4397","authenticated-orcid":false,"given":"Andrea","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Neurodegenerative Diseases, Parkinson's Disease and Movement Disorders Institute, Department of Neurology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hooman","family":"Kamel","sequence":"additional","affiliation":[{"name":"Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"COVID\u201019: data \u2010 NYC Health. 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