{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:42Z","timestamp":1786978242213,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on non\u2010motor symptoms (NMS) in black Africans with Parkinson's disease (PD) are sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the profile of NMS in the Nigeria PD Registry (NPDR) cohort and explore the relationship between NMS and PD motor phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional study of the frequency and burden of NMS, based on the non\u2010motor symptoms scale (NMSS) and the Chaudhuri method respectively in our cohort. Baseline demographics, disease characteristics (Hoehn and Yahr stage, MDS\u2010UPDRS total score and Part III motor score), motor phenotype (based on Stebbin et al's algorithm), and levodopa equivalent daily dose (LEDD) were documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data are presented for 825 PD whose mean age at study was 63.7\u2009\u00b1\u200910.1\u2009years, female sex\u2014221 [26.8%] while median PD duration was 36\u2009months. PD phenotypes included tremor\u2010dominant 466 (56.5%), postural instability and gait disorder (PIGD) 259 (31.4%), and indeterminate 100 (12.1%). 82.6% were on treatment (median LEDD of 500\u2009mg\/24\u2009hours). 804 (97.5%) endorsed at least 1 NMS. The median NMSS score was 26.0 while subscores for urinary and sexual function domains were significantly higher in males (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u20090.05). PIGD\u2010PD had more frequent NMS and higher frequency of severe\/very severe NMSS burden (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.000 for both). Nocturia and fatigue were the most prevalent NMS overall and across motor subtypes. PIGD phenotype and total UPDRS scores were the independent determinants of NMSS scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The profile and burden of NMS, and association with motor subtype in our black African cohort is largely similar to descriptions from other populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.13346","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:49:32Z","timestamp":1631839772000},"page":"1206-1215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Cross\u2010Sectional Comprehensive Assessment of the Profile and Burden of Non\u2010motor Symptoms in Relation to Motor Phenotype in the Nigeria Parkinson Disease Registry Cohort"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6461-2653","authenticated-orcid":false,"given":"Oluwadamilola O.","family":"Ojo","sequence":"first","affiliation":[{"name":"Neurology Unit, Department of Medicine, Faculty of Clinical Sciences College of Medicine, University of Lagos  Lagos Nigeria"},{"name":"Neurology Unit, Department of Medicine Lagos University Teaching Hospital  Lagos Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-1953","authenticated-orcid":false,"given":"Kolawole W.","family":"Wahab","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ilorin\/University of Ilorin Teaching Hospital  Ilorin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiodun H.","family":"Bello","sequence":"additional","affiliation":[{"name":"University of Ilorin Teaching Hospital  Ilorin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sani A.","family":"Abubakar","sequence":"additional","affiliation":[{"name":"Department of Medicine Ahmadu Bello University\/Ahmadu Bello University Teaching Hospital  Zaria Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-2021","authenticated-orcid":false,"given":"Bertha C.","family":"Ekeh","sequence":"additional","affiliation":[{"name":"University of Uyo Teaching Hospital\/Ibom Specialist Hospital  Uyo Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9753-4532","authenticated-orcid":false,"given":"Folajimi M.","family":"Otubogun","sequence":"additional","affiliation":[{"name":"Olabisi Onabanjo University Teaching Hospital  Sagamu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-3872","authenticated-orcid":false,"given":"Emmanuel U.","family":"Iwuozo","sequence":"additional","affiliation":[{"name":"Neurology Unit Benue State University\/Benue State University Teaching Hospital  Makurdi Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope H.","family":"Farombi","sequence":"additional","affiliation":[{"name":"Chief Tony Anenih Geriatrics Center, University College Hospital  Ibadan, Oyo Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3402-7768","authenticated-orcid":false,"given":"Olaleye","family":"Adeniji","sequence":"additional","affiliation":[{"name":"Federal Medical Center  Abeokuta Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4108-4995","authenticated-orcid":false,"given":"Francis I.","family":"Ojini","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Medicine, Faculty of Clinical Sciences College of Medicine, University of Lagos  Lagos 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