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Recent studies have found an association between anticholinergic medication exposure and future risk of dementia in older individuals and those with PD. These findings provide a further reason to avoid the use of anticholinergic medications to treat motor symptoms of PD. More importantly, they raise the question of whether one of the goals of PD treatment should be to deprescribe all medications with anticholinergic properties, regardless of their indication, to reduce dementia risk. In this review, we discuss the use of anticholinergic medications in PD, the evidence supporting the association between anticholinergic medications and future dementia risk, and the potential implications of these findings for clinical care in PD.<\/jats:p>","DOI":"10.1002\/mdc3.13347","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:59:00Z","timestamp":1631926740000},"page":"1181-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Antimuscarinic Anticholinergic Medications in Parkinson Disease: To Prescribe or Deprescribe?"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4480-0221","authenticated-orcid":false,"given":"Matthew J.","family":"Barrett","sequence":"first","affiliation":[{"name":"Department of Neurology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Sargent","sequence":"additional","affiliation":[{"name":"School of Nursing Virginia Commonwealth University  Richmond Virginia USA"},{"name":"Department of Pharmacotherapy and Outcomes Science, School of Pharmacy Virginia Commonwealth University  Richmond Virginia USA"},{"name":"Geriatric Pharmacotherapy Program, School of Pharmacy Virginia Commonwealth University  Richmond Virginia USA"},{"name":"Institute for Inclusion Inquiry and Innovation (iCubed): Health and Wellness in Aging Populations Core  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huma","family":"Nawaz","sequence":"additional","affiliation":[{"name":"Department of Neurology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-7168","authenticated-orcid":false,"given":"Daniel","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Parkinson's Disease Research, Education and Clinical Center Corporal Michael J. 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