{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:42:29Z","timestamp":1790671349366,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although described as non\u2010progressive, alternating hemiplegia of childhood (AHC) can display a sudden deterioration, anecdotally reported mainly in childhood. Outcome in adulthood is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Aim of this study is to describe the long\u2010term follow\u2010up of neurological function in adults with AHC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven adults with AHC were included in this retrospective single\u2010center study. Clinical history and previous investigation data were gathered from the review of medical records. Video\u2010documented neurological examination was performed at the last follow\u2010up visit in four out of the seven reported indivisuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a median follow\u2010up of 16\u2009years, neurological outcome and trajectories were heterogeneous. All individuals showed new neurological signs or symptoms. Three experienced a serious irreversible neurological deterioration after prolonged quadriplegic episodes and\/or status epilepticus in their second or third decade. One patient died at age 29.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This video\u2010series suggests that AHC in adulthood is not stationary; larger cohorts are needed to identify genotype\u2013phenotype correlations and clinically useful outcome predictors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13388","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T23:21:02Z","timestamp":1638573662000},"page":"206-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Non\u2010Stationary Outcome of Alternating Hemiplegia of Childhood into Adulthood"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-2765","authenticated-orcid":false,"given":"Marco","family":"Perulli","sequence":"first","affiliation":[{"name":"Child Neurology and Psychiatry Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"},{"name":"Department of Neuroscience Catholic University Of The Sacred Heart  Rome Italy"},{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Poole","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2413-1788","authenticated-orcid":false,"given":"Giulia","family":"Di Lazzaro","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine Tor Vergata University  Rome Italy"},{"name":"Neurology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6600-6419","authenticated-orcid":false,"given":"Sasha","family":"D'Ambrosio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Dipartimento di Scienze Biomediche e Cliniche \u201cL. Sacco\u201d Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"Chalfont Centre for Epilepsy  Bucks United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8456-0029","authenticated-orcid":false,"given":"Katri","family":"Silvennoinen","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Neuro Center Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Zagaglia","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Jim\u00e9nez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen 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