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Little is known, however, about apathy and depression among other PSP variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively studied 97 newly diagnosed PSP patients. All were classified into a PSP variant using the 2017 Movement Disorder Society\u2010PSP criteria and administered the Geriatric Depression and Apathy Evaluation Scales. Differences in apathy and depression frequency and severity across six variants, and secondarily across PSP\u2010Richardson's syndrome, PSP\u2010Cortical and PSP\u2010Subcortical, were analyzed using ANCOVA and linear regression adjusting for disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Depression (55%) was more common than apathy (12%). PSP\u2010Speech\/Language (PSP\u2010SL) variant had the lowest depression frequency (13%) and lower depression scores than the other variants. No differences in apathy frequency\/severity were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PSP\u2010SL patients may have less depression compared to PSP\u2010Richardson's syndrome and other PSP variants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13396","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:42:55Z","timestamp":1639701775000},"page":"212-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Depression and Apathy across Different Variants of Progressive Supranuclear Palsy"],"prefix":"10.1002","volume":"9","author":[{"given":"Sarah M.","family":"Bower","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen D.","family":"Weigand","sequence":"additional","affiliation":[{"name":"Department of Health 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