{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:49:45Z","timestamp":1776282585939,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periodic limb movements while awake (PLMA) are similar to Periodic limb movements in sleep (PLMS) but occurring during wakefulness and seen in association with restless leg syndrome (RLS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe PLMA as a wearing\u2010off phenomenon in Parkinson's Disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe four individuals with PD and PLMS, who had associated similar periodic and stereotypic lower extremity movements during wakefulness, thought to be secondary to PLMA, and were highly responsive to dopaminergic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite the prevalence of RLS and PLMS in individuals with PD, the presence of similar movements during wakefulness has not been well characterized. The lack of a specific diagnostic criteria poses a significant diagnostic challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe, for the first time to our knowledge, PLMA as a wearing\u2010off phenomenon in PD. This entity could be classified in the spectrum of \u201clow\u2010dose dyskinesia,\u201d as we found that it was highly responsive to dopaminergic treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13487","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T10:43:13Z","timestamp":1652352193000},"page":"652-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Periodic Limb Movements while Awake (<scp><i>PLMA<\/i><\/scp>) as a Manifestation of <scp>Wearing\u2010Off<\/scp> in Parkinson's Disease: A Case Series and Review of the Literature"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-4511","authenticated-orcid":false,"given":"Sohaila","family":"Alshimemeri","sequence":"first","affiliation":[{"name":"Edmond J. 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