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The clinical and radiological features of Multiple system atrophy type C overlap with the autosomal dominant inherited ataxias. We present a case series of 3 African patients with genetically proven Spinocerebellar Ataxia presenting with the Hot cross bun sign and a scoping review of similar studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Cases<\/jats:title><jats:p>We described the phenotypic and radiological presentation of genetically confirmed SCA\u20102 in two, and SCA\u20107 in one patient, with the \u201chot cross bun\u201d sign.<\/jats:p><\/jats:sec><jats:sec><jats:title>Literature Review<\/jats:title><jats:p>We performed a scoping review on the Hot Cross Bun Sign.<\/jats:p><jats:p>A total of 66 articles were retrieved. We describe the diverse aetiologies of the sign and associated phenotypic and radiological features. We review the Spinocerebellar Ataxias described with a Hot cross bun sign and make comparisons to Multiple System Atrophy Type C [Ref. 1,2].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge this is the first description of an African cohort presenting with the Hot Cross Bun Sign. We expand the differential diagnosis of the Hot Cross Bun Sign.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13550","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T06:39:42Z","timestamp":1661150382000},"page":"1105-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The \u201cHot Cross Bun Sign\u201d in Spinocerebellar Ataxia Types 2 and 7\u2013Case Reports and Review of Literature"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-6990","authenticated-orcid":false,"given":"Ansuya Kasavelu","family":"Naidoo","sequence":"first","affiliation":[{"name":"Greys Academic Hospital  Pietermaritzburg South Africa"},{"name":"School of Clinical Medicine, Division Neurology University of KwaZulu Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cait\u2010Lynn 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