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The primary outcome was baseline caregiver\u2010reported aggression. Using multivariate linear regression, baseline dyad characteristics (eg, measures of disease, psychosocial issues, caregiver strain) were examined to identify factors associated with aggression. Thematic analysis of interviews was used to augment these findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Associated variables included disease duration (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.15, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), patient grief (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.22, <jats:italic>P<\/jats:italic>&lt;\u20090.001), symptom burden (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.18, <jats:italic>r<\/jats:italic>\u2009&lt;\u20090.01), resistance to care (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.40, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), caregivers\u2019 depression (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.16, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and caregiving burden (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.34, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). We identified five themes: (1) Aggressive behaviors range from verbal abuse to threats of physical violence; (2) Caregivers believe that aggressive behaviors result from the difficulty patients experience in coping with disease progression and related losses; (3) Caregivers\u2019 stress and mental health are worsened by aggressive behaviors; (4) Aggressive behaviors negatively affect patient\u2013caregiver relationships; (5) Caregivers are ill\u2010prepared to manage aggressive behaviors and cope with the consequences on their own.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aggression in PDRD is driven by diverse factors (eg, grief, fluctuations in cognition) with serious consequences for caregivers. Neurologists and movement specialists should consider screening for aggression while prioritizing caregiver education and wellbeing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13555","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T06:39:46Z","timestamp":1661150386000},"page":"920-931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Aggression Towards Caregivers in Parkinson's Disease and Related Disorders: A Mixed Methods Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8900-9500","authenticated-orcid":false,"given":"Zachary A.","family":"Macchi","sequence":"first","affiliation":[{"name":"Behavioral Neurology|Neuropalliative Sections, Department of Neurology University of Colorado Anschutz  Aurora Colorado 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California, San Francisco  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Santos","sequence":"additional","affiliation":[{"name":"Division of Geriatric Mental Health and Memory Care University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H.","family":"Sillau","sequence":"additional","affiliation":[{"name":"Behavioral Neurology|Neuropalliative Sections, Department of Neurology University of Colorado Anschutz  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary D.","family":"Lum","sequence":"additional","affiliation":[{"name":"Division of Geriatric 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