{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:36Z","timestamp":1786978356331,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010term follow\u2010up of isolated rapid eye movement (REM) sleep behavior disorder (IRBD) patients reveals a high risk of \u03b1\u2010synucleinopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We explored the early clinical predictive factors of phenoconversion from IRBD to Parkinson's disease (PD) or dementia with Lewy bodies (DLB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed baseline office\u2010based cognitive test scores (Montreal Cognitive Assessment [MoCA\u2010J], Mini\u2010Mental State Examination [MMSE], and Frontal Assessment Battery [FAB]), motor function, and olfactory function in 36 consecutive polysomnography (PSG)\u2010confirmed IRBD patients with reduced metaiodobenzylguanidine (MIBG) accumulation. PD or DLB was confirmed by medical chart review retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 36 IRBD patients, 19 (n\u00a0=\u00a019, 52.8%) with abnormal MoCA\u2010J score (&lt;\u200926) had significantly lower scores in trail making B, phonetic verbal fluency sub\u2010items in the executive domain, and in delayed recall in the memory domain. In total, 12 (33.3%) patients developed PD or DLB; seven of 12 patients (58.3%) developed DLB at a mean follow\u2010up period of 6.8\u2009years. In the normal MoCA\u2010J group (n\u00a0=\u00a017, 47.2%), two patients developed PD, but none developed dementia. Furthermore, in the abnormal MoCA\u2010J group, seven patients developed DLB and three developed PD without dementia. The phenoconverter group had significantly lower scores in delayed recall in the memory domain compared to the disease\u2010free group. Cox hazard analysis showed that MoCA\u2010J was superior to MMSE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among IRBD patients with reduced cardiac MIBG accumulation, MoCA\u2010J score of &lt;26 (Mild Cognitive Impairment\u2010Lewy body) and a low sub\u2010item score for delayed recall predicted short\u2010term progression to probable DLB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.13569","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T01:29:11Z","timestamp":1663550951000},"page":"32-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Montreal Cognitive Assessment Predicts the Short\u2010Term Risk of Lewy Body Disease in Isolated\n                    <scp>REM<\/scp>\n                    Sleep Behavior Disorder with Reduced\n                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