{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:06:04Z","timestamp":1788519964282,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We describe our experience of using perampanel to treat essential tremor (ET) over 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 50 ET patients in an open\u2010label trial. Perampanel was titrated to 4\u00a0mg\/day as adjuvant therapy. The main outcome measures were baseline,\u00a0+1,\u00a0+3,\u00a0+6, and\u2009+\u200912\u00a0month scores of the Tremor Clinical Rating Scale (TCRS) and the Glass scale (GS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients withdrew because of adverse effects. At +1\u2009month, 27 of 30 patients improved: 68% reduction in both TCRS 1\u2009+\u20092 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and TCRS 3 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001); TCRS 4\u2009+\u20091.8 and GS 1.1 point reduction. By +12\u00a0months non\u2010persistence of therapeutic effect occurred in 70% of patients: the mean reduction in TCRS 1\u2009+\u20092 was 33% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), TCRS 3 (0.04), TCRS 4\u2009+\u20090.8, GS 0.2 points reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report important peramapanel acute tremorolytic effects, but poor tolerance to adverse effects and a non\u2010sustained therapeutic effect in most patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13576","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T03:59:43Z","timestamp":1664164783000},"page":"74-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Non\u2010Persistence of Tremorolytic Effect of Perampanel in Essential Tremor: Real\u2010World Experience with 50 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