{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:41:12Z","timestamp":1771260072134,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Functional movement disorders (FMD) are a commonly under\u2010recognized diagnosis in patients with underlying neurodegenerative diseases. FMD have been observed in patients undergoing deep brain stimulation (DBS) for Parkinson's disease (PD) and other movement disorders. The prevalence of coexisting FMD among movement disorder\u2010related DBS patients is unknown, and it may occur more often than previously recognized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed the relative prevalence and clinical characteristics of FMD occurring post\u2010DBS, in PD and dystonia patients (FMD+, n\u00a0=\u00a029). We compared this cohort with age at surgery\u2010, sex\u2010, and diagnosis\u2010matched subjects without FMD post\u2010DBS (FMD\u2212, n\u00a0=\u00a029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the FMD prevalence (0.2%\u20132.1%) and the number of cases\/DBS procedures\/year varied across centers (0.15\u20133.65). A total of nine of 29 FMD+ cases reported worse outcomes following DBS. Although FMD+ and FMD\u2212 manifested similar features, FMD+ showed higher psychiatric comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DBS may be complicated by the development of FMD in a subset of patients, particularly those with pre\u2010morbid psychiatric conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13609","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T01:40:05Z","timestamp":1667180405000},"page":"94-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Functional Movement Disorders and Deep Brain Stimulation: A Multi\u2010Center Study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6438-9911","authenticated-orcid":false,"given":"Luca","family":"Marsili","sequence":"first","affiliation":[{"name":"Gardner Family Center for Parkinson's disease and Movement Disorders  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth G.","family":"Keeling","sequence":"additional","affiliation":[{"name":"School of Life Sciences Arizona State University  Tempe Arizona USA"},{"name":"Barrow Neurological Institute  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Maciel","sequence":"additional","affiliation":[{"name":"Edmond J. Safra Program in Parkinson's Disease Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN  Toronto Ontario Canada"},{"name":"Canada Division of Neurology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fiorella","family":"Contarino","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Neurology Haga teaching Hospital  The Hague The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodi","family":"Zutt","sequence":"additional","affiliation":[{"name":"Department of Neurology Haga teaching Hospital  The Hague The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Okun","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neurosurgery Norman Fixel Institute for Neurological Diseases, University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neurosurgery Norman Fixel Institute for Neurological Diseases, University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wissam","family":"Deeb","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neurosurgery Norman Fixel Institute for Neurological Diseases, University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-3787","authenticated-orcid":false,"given":"Drew","family":"Kern","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neurosurgery University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Macias\u2010Garcia","sequence":"additional","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda Cl\u00ednica Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Seville Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda Cl\u00ednica Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Seville Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-302X","authenticated-orcid":false,"given":"Pablo","family":"Mir","sequence":"additional","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda Cl\u00ednica Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Seville Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"},{"name":"Departamento de Medicina Facultad de Medicina, Universidad de Sevilla  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristide","family":"Merola","sequence":"additional","affiliation":[{"name":"Department of Neurology The Ohio State Wexner Medical Center  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto J.","family":"Espay","sequence":"additional","affiliation":[{"name":"Gardner Family Center for Parkinson's disease and Movement Disorders  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5346-0180","authenticated-orcid":false,"given":"Alfonso","family":"Fasano","sequence":"additional","affiliation":[{"name":"Edmond J. 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