{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:48:01Z","timestamp":1761864481874,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Insulin\u2010like growth factor 1 (IGF\u20101) seems to be involved in the neural circuits associated with social cognition and brain structure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the association of IGF\u20101 levels with social cognition and brain structure in Huntington's disease (HD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated social cognition using the Ekman test in 22 HD patients and 19 matched controls. Brain structure was assessed using standard volume\u2010based voxel\u2010based morphometry and surface\u2010based cortical thickness pipeline. We analyzed the association of IGF\u20101 levels with social cognition and brain structure using adjusted regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Social cognition was worse in HD patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), on antidopaminergic drugs (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), and with lower IGF\u20101 levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). In neuroimaging analyses, lower IGF\u20101 levels were associated with social cognition impairment and atrophy mainly in frontotemporal regions (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 corrected).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In HD, abnormal IGF\u20101 function seems to be associated with brain atrophy leading to clinical deficits in social cognition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13613","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T08:14:51Z","timestamp":1668500091000},"page":"279-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between <scp>Insulin\u2010Like<\/scp> Growth Factor\u20101 and Social Cognition in Huntington's Disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Cecilia","family":"Gil\u2010Polo","sequence":"first","affiliation":[{"name":"Neurology Department 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