{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T18:11:28Z","timestamp":1766599888807,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013327","name":"H. Lundbeck A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013327","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical Impression of Severity Index for Parkinson's Disease (CISI\u2010PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health\u2010related quality of life and the CISI\u2010PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the association of CISI\u2010PD scores with those of generic (EQ\u20105D\u20105L) and Parkinson's disease (PD) disease\u2010specific (Parkinson's Disease Questionnaire\u20138 [PDQ\u20108]) health\u2010related quality of life assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Persons with idiopathic PD in the Swedish Parkinson's Disease registry with simultaneous registrations of CISI\u2010PD and EQ\u20105D\u20105L and\/or PDQ\u20108 were included. Correlations with EQ\u20105D dimensions were analyzed. The relationships between the CISI\u2010PD, EQ\u20105D\u20105L, and PDQ\u20108 were estimated by linear mixed models with random intercept.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the Swedish Parkinson's Disease registry, 3511 registrations, among 2168 persons, fulfilled the inclusion criteria. The dimensions self\u2010care, mobility, and usual activities correlated moderately with the CISI\u2010PD (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.60, <jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.54, <jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.57). Weak correlations were found for anxiety\/depression and pain\/discomfort (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.39, <jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.29) (<jats:italic>P<\/jats:italic> values &lt;\u20090.001). The fitted model included the CISI\u2010PD, age, sex, and time since diagnosis. The CISI\u2010PD had a statistically significant impact on the EQ\u20105D and PDQ\u20108 (<jats:italic>P<\/jats:italic> values &lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CISI\u2010PD provides a moderate correlation with the EQ\u20105D and could possibly be useful as a basis for defining health states in future health economic models and serving as outcomes in managed entry agreements. Nonetheless, the limitation of capturing nonmotor symptoms of the disease remains a shortcoming of clinical instruments, including the CISI\u2010PD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13649","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T10:18:15Z","timestamp":1672049895000},"page":"392-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Impression of Severity Index for Parkinson's Disease and Its Association to <scp>Health\u2010Related<\/scp> Quality of Life"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5402-1884","authenticated-orcid":false,"given":"Jenny M.","family":"Norlin","sequence":"first","affiliation":[{"name":"The Swedish Institute for Health Economics  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-2847","authenticated-orcid":false,"given":"Klas","family":"Kellerborg","sequence":"additional","affiliation":[{"name":"The Swedish Institute for Health Economics  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-6475","authenticated-orcid":false,"given":"Ulf","family":"Persson","sequence":"additional","affiliation":[{"name":"The Swedish Institute for Health Economics  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-417X","authenticated-orcid":false,"given":"Daniel Oudin","family":"\u00c5str\u00f6m","sequence":"additional","affiliation":[{"name":"H Lundbeck A\/S  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2174-372X","authenticated-orcid":false,"given":"Peter","family":"Hagell","sequence":"additional","affiliation":[{"name":"The PRO\u2010CARE Group, Faculty of Health Sciences Kristianstad University  Kristianstad Sweden"},{"name":"Restorative Parkinson Unit, Division of Neurology, Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-5280","authenticated-orcid":false,"given":"Pablo","family":"Martinez\u2010Martin","sequence":"additional","affiliation":[{"name":"Center of Networked Biomedical Research in Neurodegenerative Diseases Carlos III Institute of Health  Madrid 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