{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:47:46Z","timestamp":1778906866780,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Deep brain stimulation of the subthalamic nucleus (STN\u2010DBS) is an effective treatment for Parkinson's disease (PD). The long\u2010term benefit in PD patients with STN\u2010DBS in comparison to medical treatment (MT) alone has not yet been demonstrated conclusively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To judge the long\u2010term outcome of patients with STN\u2010DBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To assess the evolution of PD symptoms and health\u2010related quality of life (HRQoL) after deep brain stimulation (DBS) surgery, we conducted a cross\u2010sectional analysis of 115 patients with STN\u2010DBS with rater\u2010based scales and self\u2010reported questionnaires. In addition, we screened records of all our STN\u2010DBS patients (2001\u20132019, n\u00a0=\u00a0162 patients) for the onset of the morbidity milestones (falls, hallucinations, dementia, and nursing home placement) to assess disability\u2010free life expectancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first year of STN\u2010DBS, levodopa equivalent dose was reduced and motor function improved. Nonmotor symptoms and cognition remained stable. These effects were similar to previous studies. Morbidity milestones occurred 13\u2009\u00b1\u20097\u2009years after diagnosis. Motor function, cognition, and HRQoL significantly worsened after the occurrence of any milestone, confirming the clinical relevance of these milestones. After onset of the first milestone, mean survival time was limited to 5\u2009\u00b1\u20090.8\u2009years, which is comparable with patients with PD but without STN\u2010DBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>On average, PD patients with STN\u2010DBS live with their disease for a longer time, and morbidity milestones occur later in the disease course than in PD patients with MT. As judged by morbidity milestones, morbidity remains compressed into the final 5\u2009years of life in PD patients with STN\u2010DBS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13698","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:14:30Z","timestamp":1675988070000},"page":"569-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Morbidity Milestones Demonstrate Long Disability\u2010Free Survival in Parkinson's Disease Patients with Deep Brain Stimulation of the Subthalamic Nucleus"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-8105","authenticated-orcid":false,"given":"Nils","family":"Schnalke","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus  Dresden Germany"},{"name":"German Center for Neurodegenerative Diseases  Dresden 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