{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:23:47Z","timestamp":1783664627685,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To date, a few studies have systematically investigated differences in the clinical spectrum between acquired and idiopathic dystonias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare demographic data and clinical features in patients with adult\u2010onset acquired and idiopathic dystonias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were identified from among those included in the Italian Dystonia Registry, a multicenter Italian dataset of patients with adult\u2010onset dystonia. Study population included 116 patients with adult\u2010onset acquired dystonia and 651 patients with isolated adult\u2010onset idiopathic dystonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparison of acquired and idiopathic dystonia revealed differences in the body distribution of dystonia, with oromandibular dystonia, limb and trunk dystonia being more frequent in patients with acquired dystonia. The acquired dystonia group was also characterized by lower age at dystonia onset, greater tendency to spread, lower frequency of head tremor, sensory trick and eye symptoms, and similar frequency of neck pain associated with CD and family history of dystonia\/tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinical phenomenology of dystonia may differ between acquired and idiopathic dystonia, particularly with regard to the body localization of dystonia and the tendency to spread. This dissimilarity raises the possibility of pathophysiological differences between etiologic categories.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13801","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T08:35:00Z","timestamp":1685435700000},"page":"1107-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phenotypic Variability in Acquired and Idiopathic Dystonia"],"prefix":"10.1002","volume":"10","author":[{"given":"Giovanni","family":"Defazio","sequence":"first","affiliation":[{"name":"Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1593-5867","authenticated-orcid":false,"given":"Angelo Fabio","family":"Gigante","sequence":"additional","affiliation":[{"name":"Section of Neurology San Paolo Hospital  Bari 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