{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:53:00Z","timestamp":1776437580565,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since 2014, there has been increasing public outreach effort regarding isolated\/idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) in Montreal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess if, over time, milder iRBD cases are presenting earlier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Disease\u2010free survival was compared in two iRBD recruitment epochs: 2004 to 2013 (\u201cearlier\u201d) versus 2014to 2022 (\u201clater<jats:italic>\u201d<\/jats:italic>) and by referral type (\u201cself\u2010referral\u201d vs. \u201cconventional\u2010referral\u201d) in three large centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Montreal, among 209 subjects followed prospectively, shorter time to phenoconversion was observed in the earlier epoch (5\u2010year phenoconversion\u2009=\u200942% earlier vs. 23% later); diagnosis before 2014 had a 1.8\u2010fold phenoconversion hazard. However, no difference was observed in 248 subjects from Barcelona and 166 from Innsbruck. Analysis of Montreal data found that increased survival in the later epoch was driven by an increasing number of self\u2010referrals, who phenoconverted at 1\/3 the rate of physician\u2010referred subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased patient awareness of iRBD results in earlier presentation to clinical attention, with a longer time to phenoconversion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13842","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T07:20:17Z","timestamp":1689578417000},"page":"1519-1524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is <scp>REM<\/scp> Sleep Behavior Disorder Changing? Secular Changes Versus Referral Patterns"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5598-4110","authenticated-orcid":false,"given":"Stephen","family":"Joza","sequence":"first","affiliation":[{"name":"Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Iranzo","sequence":"additional","affiliation":[{"name":"Neurology Service, Sleep Disorders Center Hospital Cl\u00ednic de Barcelona, University of Barcelona, IDIBAPS, CIBERNED  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4259-8824","authenticated-orcid":false,"given":"Ambra","family":"Stefani","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelie","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute McGill University  Montreal Quebec Canada"},{"name":"Centre d'\u00c9tudes Avanc\u00e9es en M\u00e9decine du Sommeil H\u00f4pital du Sacr\u00e9\u2010C\u0153ur de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Serradell","sequence":"additional","affiliation":[{"name":"Neurology Service, Sleep Disorders Center Hospital Cl\u00ednic de Barcelona, University of Barcelona, IDIBAPS, CIBERNED  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaia","family":"Mu\u00f1oz\u2010Lopetegi","sequence":"additional","affiliation":[{"name":"Neurology Service, Sleep Disorders Center Hospital Cl\u00ednic de Barcelona, University of Barcelona, IDIBAPS, CIBERNED  Barcelona 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