{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:38:39Z","timestamp":1781624319293,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010 173540"],"award-info":[{"award-number":["PJT\u2010 173540"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are atypical parkinsonisms (APs) that are classified as tauopathies. Patients with these APs may present with similar early clinical manifestations to Parkinson's disease (PD), but they prove unresponsive to anti\u2010parkinsonian medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The main objective of this meta\u2010analysis was to compare first\u2010 and second\u2010generation tau PET tracer efficacy in patients with the APs to identify potential diagnostic biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed and Web of Science were searched between January 1, 1999 and December 31, 2022. We included case\u2013control studies that were published in English and report tau PET tracer binding as mean\u2009\u00b1\u2009SD in at least one region of interest (ROI). Differences in tau PET binding values were meta\u2010analyzed using random\u2010effects meta\u2010analytic models and subgroup analyses based on ROIs in the statistical programming language R (version 4.2.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 29 studies with 665 patients were included in the final review. [<jats:sup>18<\/jats:sup>F]PI\u20102620 outperformed first\u2010generation tracers when comparing PSP\u2010HC (<jats:italic>g<\/jats:italic>\u2009=\u2009\u22121.68, 95% CI: \u22122.05 to \u22121.30) and CBD\u2010HC (<jats:italic>g<\/jats:italic>\u2009=\u2009\u22121.37, 95% CI: \u22122.25 to \u22120.49). When comparing PSP\u2010PD, the first\u2010generation tracer, [<jats:sup>18<\/jats:sup>F]AV\u20101451, presented with higher binding to PSP patients (<jats:italic>g<\/jats:italic>\u2009=\u2009\u22120.80, 95% CI: \u22121.24 to \u22120.35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate the efficacy of [<jats:sup>18<\/jats:sup>F]PI\u20102620 PET in imaging AP\u2010tau. These findings contribute towards identifying a diagnostic imaging biomarker for patients with APs. The main limitation of this study was the heterogeneity of the results. Future studies should conduct AP\u2010PD comparisons with second\u2010generation tracers to confirm the preliminary results found here.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13885","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T09:14:07Z","timestamp":1695114847000},"page":"1725-1737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tau in Atypical Parkinsonisms: A Meta\u2010Analysis of in Vivo <scp>PET<\/scp> Imaging Findings"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-0240","authenticated-orcid":false,"given":"Anastassia M.","family":"Mena","sequence":"first","affiliation":[{"name":"Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health University of Toronto  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Division of Brain, Imaging and Behaviour\u2013Systems Neuroscience, Krembil Brain Institute, UHN University of Toronto  Toronto Ontario Canada"},{"name":"Edmond J. Safra Parkinson Disease Program &amp; Morton and Gloria Shulman Movement Disorder Unit, Neurology Division, Department of Medicine, Toronto Western Hospital, UHN University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Graff\u2010Guerrero","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health University of Toronto  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Martin","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Uribe","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio P.","family":"Strafella","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health University of Toronto  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Division of Brain, Imaging and Behaviour\u2013Systems Neuroscience, Krembil Brain Institute, UHN University of Toronto  Toronto Ontario Canada"},{"name":"Edmond J. 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