{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:10:29Z","timestamp":1792696229697,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018889","name":"Multiple System Atrophy Coalition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018889","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individuals with multiple system atrophy (MSA) often complain about pain, nonetheless this remains a poorly investigated non\u2010motor feature of MSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Here, we aimed at assessing the prevalence, characteristics, and risk factors for pain in individuals with MSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyzes (PRISMA) guidelines, we systematically screened the PubMED, Cochrane, and Web of Science databases for papers published in English until September 30, 2022, combining the following keywords: \u201cpain,\u201d \u201cmultiple system atrophy,\u201d \u201cMSA,\u201d \u201colivopontocerebellar atrophy,\u201d \u201cOPCA,\u201d \u201cstriatonigral degeneration,\u201d \u201cSND,\u201d \u201cShy Drager,\u201d and \u201catypical parkinsonism.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The search identified 700 records. Sixteen studies provided information on pain prevalence in cohorts of MSA individuals and were included in a qualitative assessment based on the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Thirteen studies (11 cross\u2010sectional, two longitudinal) scored \u226514 points on QUADAS assessment and were included in a quantitative analysis, pooling data from 1236 MSA individuals. The resulting pooled prevalence of pain in MSA was 67% (95% confidence intervals [CI] =\u200957%\u201375%), and significantly higher in individuals with MSA of parkinsonian rather than cerebellar type (76% [95% CI\u2009=\u200963%\u201387%] vs. 45% [95% CI\u2009=\u200933%\u201357%],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001). Pain assessment tools and collected information were highly heterogeneous across studies. Two studies reported pain treatment strategies and found that only every second person with MSA complaining about pain had received targeted treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that pain is a frequent, but still under\u2010recognized and undertreated feature of MSA. Further research is needed to improve pain detection and treatment in MSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.13897","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T07:25:42Z","timestamp":1695972342000},"page":"1738-1749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pain in Multiple System Atrophy a Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-3086","authenticated-orcid":false,"given":"Nicole","family":"Campese","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Cali\u00f2","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck 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