{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:12:09Z","timestamp":1780589529474,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004313","name":"General Electric","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004830","name":"Siemens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004830","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cognitive reserve (CR) is the mismatch between preserved cognition and neuropathological damage. Amyloidopathy in Parkinson's disease (PD) could be associated with faster progression to dementia, but the putative protective effect of CR is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of CR on \u03b2\u2010amyloid burden and brain metabolism in non\u2010demented PD subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with PD (n\u2009=\u200953) underwent a clinical evaluation, [<jats:sup>18<\/jats:sup>F]\u2010fluorodeoxyglucose and [<jats:sup>18<\/jats:sup>F]\u2010flutemetamol positron emission tomography magnetic resonances, and were classified according to CR. The metabolic pattern of 16 controls was compared to PD subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PD subjects showed hypometabolism mainly in the bilateral posterior cortex. Superior\u2010CR subjects (n\u2009=\u200922) exhibited better cognitive performance, increased amyloid burden, and higher metabolism in several right hemisphere areas compared to low\u2010medium\u2010CR subjects (n\u2009=\u200931).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher CR in non\u2010demented PD is associated with better cognitive performance, which might reduce vulnerability to the effect of \u03b2\u2010amyloid. Whether superior CR leads to protection against metabolic deterioration, and predominantly right hemisphere involvement, deserves further exploration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13967","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T08:22:26Z","timestamp":1704270146000},"page":"282-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cognitive Reserve in Parkinson's Disease without Dementia: \u03b2\u2010Amyloid and Metabolic Assessment"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9676-2883","authenticated-orcid":false,"given":"Beatriz","family":"Fern\u00e1ndez\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"PhD Program in Neuroscience, Autonoma de Madrid 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