{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:55:19Z","timestamp":1783000519415,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014421","name":"EA Pharma Co., Ltd.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic constipation is a common digestive complication of Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To verify the usefulness of elobixibat, an ileal bile acid transporter inhibitor, for chronic constipation in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010blind, placebo\u2010controlled study consisted of a 2\u2010week observation\/washout period and a 4\u2010week treatment period. All patients received a Bowel Movement Diary at Week \u20102 and were allocated to elobixibat (10\u2009mg) or placebo at Week 0. Patients visited at Weeks 2 and 4 to report daily spontaneous bowel movements (SBM), stool form, drug use, quality of life (QOL), and safety. Changes in these parameters were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 38 patients in the elobixibat group and 39 in the placebo group, and 37 each completed the study. SBM frequency\/week (mean\u2009\u00b1\u2009standard deviation) increased significantly from 4.2\u2009\u00b1\u20092.6 at baseline to 5.9\u2009\u00b1\u20093.2 at Week 4 in the elobixibat group (<jats:italic>P<\/jats:italic>\u2009=\u20090.0079), but not in the placebo group (4.5\u2009\u00b1\u20092.7 to 5.3\u2009\u00b1\u20093.5; <jats:italic>P<\/jats:italic>\u2009=\u20090.0889). On analysis of covariance, the between\u2010group difference in frequency changes at Week 4 (primary endpoint) was not significant after adjustment by baseline and sex (point estimate\u2009=\u20090.8; 95% confidence interval\u2009=\u2009\u22120.57 to 2.09, <jats:italic>P<\/jats:italic>\u2009=\u20090.2601), although a significant difference (<jats:italic>P<\/jats:italic>\u2009=\u20090.0011) was evidenced at Week 1 by a similar analysis. Stool form and scores of satisfaction and stigma were improved by elobixibat. Adverse events were as previously reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elobixibat improved the SBM frequency, though the defined primary endpoint was not evidenced. QOL parameters (stool consistency and treatment satisfaction) were also improved. Elobixibat may have therapeutic benefits in PD patients suffering from chronic constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration Information<\/jats:title><jats:p>Trial Registration Number: JPRN\u2010jRCTs031200172 (submitted: October 26, 2020; first patient enrolment: December 23, 2020; <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/jrct.niph.go.jp\/en-latest-detail\/jRCTs031200172\">https:\/\/jrct.niph.go.jp\/en-latest-detail\/jRCTs031200172<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13972","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T04:14:22Z","timestamp":1706069662000},"page":"352-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and Safety of Elobixibat in Parkinson's Disease with Chronic Constipation: <scp>CONST\u2010PD<\/scp> Study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6808-0444","authenticated-orcid":false,"given":"Taku","family":"Hatano","sequence":"first","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-5367","authenticated-orcid":false,"given":"Genko","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Shimo","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Nerima Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Ogaki","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Urayasu Hospital  Urayasu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7762-3597","authenticated-orcid":false,"given":"Noriko","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Urayasu Hospital  Urayasu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0021-0708","authenticated-orcid":false,"given":"Taiji","family":"Tsunemi","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7335-0672","authenticated-orcid":false,"given":"Takashi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Urayasu Hospital  Urayasu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Nerima Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9177-9587","authenticated-orcid":false,"given":"Kensuke","family":"Daida","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohide","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Urayasu Hospital  Urayasu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Fukae","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Nerima Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Sako","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Shiina","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Urayasu Hospital  Urayasu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Oji","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Wakamori","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9732-8488","authenticated-orcid":false,"given":"Shinji","family":"Saiki","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayami","family":"Okuzumi","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Takeshige\u2010Amano","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhito","family":"Fuse","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Nerima Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Nerima Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Kano","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo Nerima Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9408-7893","authenticated-orcid":false,"given":"Hikaru","family":"Kamo","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6936-2478","authenticated-orcid":false,"given":"Atsuhiko","family":"Shindo","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotake","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Juntendo Clinical Research and Trial Center Juntendo University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27602"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00007-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00307-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16790-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13082"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-160982"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00900.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080115"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23884"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.997211"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27602"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12370"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13448"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X14528269"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30123-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-054129"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.6.818"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0825-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02260863"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0231-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1383-5"},{"key":"e_1_2_9_27_1","unstructured":"Common Technical Document section 1.5 for Goofice 5 mg tablets by EA Pharma Co. Ltd. (in Japanese);2020.https:\/\/www.pmda.go.jp\/drugs\/2018\/P20180201001\/index.htmlAccessed 2 May 2023."},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-312283"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445751"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191683"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1983.04050030045008"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109908"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.35.276"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065527"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000201565"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21243"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182574f28"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02243-w"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502815"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13571"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm22004"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.13972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:28:12Z","timestamp":1760963292000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.13972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/mdc3.13972"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.13972","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,24]]},"assertion":[{"value":"2023-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}