{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:29:15Z","timestamp":1776785355601,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI82\u2010B00"],"award-info":[{"award-number":["KLI82\u2010B00"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004061","name":"Oesterreichische Nationalbank","doi-asserted-by":"publisher","award":["14171"],"award-info":[{"award-number":["14171"]}],"id":[{"id":"10.13039\/501100004061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Advanced imaging techniques have been studied for differential diagnosis between PD, MSA, and PSP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to validate the utility of individual voxel\u2010based morphometry techniques for atypical parkinsonism in a blinded fashion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight healthy controls (HC) T1\u2010WI were used to develop a referential dataset and fit a general linear model after segmentation into gray matter (GM) and white matter (WM) compartments. Segmented GM and WM with PD (n\u2009=\u200996), MSA (n\u2009=\u200918), and PSP (n\u2009=\u200920) were transformed into <jats:italic>z<\/jats:italic>\u2010scores using the statistics of referential HC and individual voxel\u2010based <jats:italic>z<\/jats:italic>\u2010score maps were generated. An imaging diagnosis was assigned by two independent raters (trained and untrained) blinded to clinical information and final diagnosis. Furthermore, we developed an observer\u2010independent index for ROI\u2010based automated differentiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diagnostic performance using voxel\u2010based z\u2010score maps by rater 1 and rater 2 for MSA yielded sensitivities: 0.89, 0.94 (95% CI: 0.74\u20131.00, 0.84\u20131.00), specificities: 0.94, 0.80 (0.90\u20130.98, 0.73\u20130.87); for PSP, sensitivities: 0.85, 0.90 (0.69\u20131.00, 0.77\u20131.00), specificities: 0.98, 0.94 (0.96\u20131.00, 0.90\u20130.98). Interrater agreement was good for MSA (Cohen's kappa: 0.61), and excellent for PSP (0.84). Receiver operating characteristic analysis using the ROI\u2010based new index showed an area under the curve (AUC): 0.89 (0.77\u20131.00) for MSA, and 0.99 (0.98\u20131.00) for PSP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These evaluations provide support for the utility of this imaging technique in the differential diagnosis of atypical parkinsonism demonstrating a remarkably high differentiation accuracy for PSP, suggesting potential use in clinical settings in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.13987","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T01:22:09Z","timestamp":1707268929000},"page":"381-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Blinded Evaluation of Brain Morphometry for Differential Diagnosis of Atypical Parkinsonism"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-4377","authenticated-orcid":false,"given":"Kazuya","family":"Kawabata","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University Innsbruck  Innsbruck Austria"},{"name":"Department of Neurology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4493-5073","authenticated-orcid":false,"given":"Florian","family":"Krismer","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University Innsbruck  Innsbruck Austria"},{"name":"Neuroimaging Research Core Facility Medical University Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6749-3044","authenticated-orcid":false,"given":"Beatrice","family":"Heim","sequence":"additional","affiliation":[{"name":"Department 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