{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:09:16Z","timestamp":1788232156257,"version":"build-2803163510"},"reference-count":122,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although Huntington's disease (HD) is usually thought of as a triad of motor, cognitive, and psychiatric symptoms, there is growing appreciation of HD as a systemic illness affecting the entire body.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This review aims to draw attention to these systemic non\u2010motor symptoms in HD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified relevant studies published in English by searching MEDLINE (from 1966 to September 2023), using the following subject headings: Huntington disease, autonomic, systemic, cardiovascular, respiratory, gastrointestinal, urinary, sexual and cutaneous, and additional specific symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 123 articles were critically reviewed with focus on systemic features associated with HD, such as cardiovascular, respiratory, gastrointestinal, urinary, sexual and sweating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This systematic review draws attention to a variety of systemic and autonomic co\u2010morbidities in patients with HD. Not all of them correlate with the severity of the primary HD symptoms or CAG repeats. More research is needed to better understand the pathophysiology and treatment of systemic and autonomic dysfunction in HD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14029","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T06:10:11Z","timestamp":1711433411000},"page":"453-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Systemic Symptoms in Huntington's Disease: A Comprehensive Review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1704-3683","authenticated-orcid":false,"given":"Raja","family":"Mehanna","sequence":"first","affiliation":[{"name":"Department of Neurology University of Texas Health Science Center at Houston, McGovern Medical School  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Jankovic","sequence":"additional","affiliation":[{"name":"Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.09.022"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.003"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00177-5"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09263-7"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02973.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7494-5"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.11.015"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-160224"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2021.102775"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.12.911"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13630"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12596"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00252-6"},{"key":"e_1_2_13_16_1","first-page":"93","article-title":"Sleep and circadian dysfunction in neurodegenerative disorders: insights from a mouse model of Huntington's disease","volume":"51","author":"Kuljis D","year":"2012","journal-title":"Minerva Pneumol"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1077"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.6.726"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.09.013"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02215-2015"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000435833"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72250-w"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14953"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11080714"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-170280"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.6.2.147"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.5603\/JNNS.a2020.0025"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.10.1248"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1748"},{"key":"e_1_2_13_30_1","first-page":"291","article-title":"Do disruptions in the circadian timing system contribute to autonomic dysfunction in Huntington's disease?","volume":"92","author":"Park S","year":"2019","journal-title":"Yale J Biol Med"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2009.01251.x"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1266"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13289"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.08.019"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24406"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24428"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.10.033"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197975"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28062"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27976"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-130083"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.238113"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004550"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.12.011"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-2012-120004"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147269"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10090589"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525415"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-020-02304-z"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.04.014"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-130054"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-020-00669-2"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.hd.858b4cc7f235df068387e9c20c436a79"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12308"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116089"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-180324"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00559"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000065888.88988.6E"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1103-13.2013"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-2012-120006"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00675.2015"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339528"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac253"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-020-02299-7"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0742-6"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12190"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12115"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30143-5"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax3338"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-200394"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-015-9318-y"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz295"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14706"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220068110"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.32"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004024"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.810810"},{"key":"e_1_2_13_78_1","first-page":"325","article-title":"Huntington's disease\u2010induced cardiac disorders affect multiple cellular pathways","volume":"2","author":"Melkani GC","year":"2016","journal-title":"React Oxyg Species (Apex)"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13188"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1293"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-89"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.07.004"},{"key":"e_1_2_13_83_1","first-page":"87","article-title":"Respiratory abnormalities in Huntington's disease","volume":"232","author":"Leopold NA","year":"1985","journal-title":"J Neurol"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6448-9_5"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00710"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215514564087"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14076"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000200108"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-010-9302-4"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.11.77"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-190390"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2021.09.005"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.11.69"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0310-1"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000031791.10922.CF"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.05.006"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.09.001"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004962"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2004.12.012"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200001)47:1<64::AID-ANA11>3.0.CO;2-S"},{"key":"e_1_2_13_101_1","first-page":"78","article-title":"Relationship between nutritional status and the severity of Huntington's disease. A Spanish multicenter dietary intake study","volume":"4","author":"Cubo E","year":"2015","journal-title":"J Huntingtons Dis"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11418-y"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22451"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1985.tb08987.x"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11884-016-0372-5"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008906"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22262"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11930-017-0123-4"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.03.006"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105488"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64074-1.00047-1"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505887"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00126.2014"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.10.004"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp243"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005021"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2015.12.013"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59602-4.00004-6"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117593"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14598"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e318261410f"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1768158"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a55f05"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.14029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:52:59Z","timestamp":1760953979000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.14029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":122,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/mdc3.14029"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.14029","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,26]]},"assertion":[{"value":"2023-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}