{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:46:26Z","timestamp":1791942386033,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Increasing levodopa (L\u2010dopa)\/dopa decarboxylase inhibitor (DDCI) daily dose or adding a catechol\u2010O\u2010methyltransferase (COMT) inhibitor to levodopa\/DDCI therapy are strategies used to manage wearing\u2010off symptoms in Parkinson's disease (PD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the COMT inhibitor opicapone versus an additional dose of levodopa to treat early wearing\u2010off in PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      ADOPTION was a randomized, parallel\u2010group, open\u2010label, Phase 4 study conducted in Korea. At baseline, eligible patients were randomized (1:1) to opicapone 50\u2009mg (n\u2009=\u200987) or L\u2010dopa 100\u2009mg (n\u2009=\u200981) (added to current L\u2010dopa\/DDCI therapy) for 4\u2009weeks. The main efficacy endpoint was change from baseline to end of study in absolute\n                      <jats:italic>off<\/jats:italic>\n                      time. Other endpoints included changes in\n                      <jats:italic>on<\/jats:italic>\n                      time, in Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale and 8\u2010item PD Questionnaire scores, and the Clinical and Patient Global Impression of Improvement\/Change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The adjusted mean in absolute\n                      <jats:italic>off<\/jats:italic>\n                      time was significantly greater for opicapone 50\u2009mg than for L\u2010dopa 100\u2009mg (\u221262.1 vs. \u221216.7\u2009minutes;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0015). Opicapone\u2010treated patients also reported a greater reduction in the percentage of\n                      <jats:italic>off<\/jats:italic>\n                      time (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0015), a greater increase in absolute\n                      <jats:italic>on<\/jats:italic>\n                      time (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0338) and a greater increase in the percentage of\n                      <jats:italic>on<\/jats:italic>\n                      time (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0015). There were no significant differences in other secondary endpoints. The L\u2010dopa equivalent daily dose was significantly higher in the opicapone group (750.9 vs. 690.0\u2009mg;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0247), when a 0.5 conversion factor is applied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Opicapone 50\u2009mg was more effective than an additional 100\u2009mg\u2009L\u2010dopa dose at decreasing\n                      <jats:italic>off<\/jats:italic>\n                      time in patients with PD and early wearing\u2010off.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14030","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:09:47Z","timestamp":1712707787000},"page":"655-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Opicapone to Treat Early Wearing\u2010off in Parkinson's Disease Patients: The Korean\n                    <scp>ADOPTION<\/scp>\n                    Trial"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-2075","authenticated-orcid":false,"given":"Jee\u2010Young","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology SMG\u2010SNU Boramae Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-9779","authenticated-orcid":false,"given":"Hyeo\u2010il","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology Hallym University Sacred Heart Hospital  Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3950-5113","authenticated-orcid":false,"given":"Joaquim J.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"IMM \u2013 Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa  Lisbon Portugal"},{"name":"CNS \u2013 Campus Neurol\u00f3gico  Torres Vedras Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-4850","authenticated-orcid":false,"given":"Jos\u00e9\u2010Francisco","family":"Rocha","sequence":"additional","affiliation":[{"name":"BIAL \u2013 Portela &amp; C<sup>a<\/sup> S.A  Coronado Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2840-1338","authenticated-orcid":false,"given":"Young Hee","family":"Sung","sequence":"additional","affiliation":[{"name":"Gachon 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