{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:10:34Z","timestamp":1780107034588,"version":"3.54.0"},"reference-count":73,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary orthostatic tremor (OT) can affect patients\u2019 life. Treatment of OT with deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (Vim) is described in a limited number of patients. The Vim and posterior subthalamic area (PSA) can be targeted in a single trajectory, allowing both stimulation of the Vim and\/or dentatorubrothalamic tract (DRT). In essential tremor this is currently often used with positive effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of Vim\/DRT\u2010DBS in OT\u2010patients, based on standing time and Quality of Life (QoL), also on the long\u2010term. Furthermore, to relate stimulation of the Vim and DRT, medial lemniscus (ML) and pyramidal tract (PT) to beneficial clinical and side\u2010effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine severely affected OT\u2010patients received bilateral Vim\/DRT\u2010DBS. Primary outcome measure was standing time; secondary measures included self\u2010reported measures, neurophysiological measures, structural analyses, surgical complications, stimulation\u2010induced side\u2010effects, and QoL up to 56\u2009months. Stimulation of volume of tissue activated (VTA) were related to outcome measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Average maximum standing time increased from 41.0\u2009s\u2009\u00b1\u200951.0\u2009s to 109.3\u2009s\u2009\u00b1\u200965.0\u2009s after 18\u2009months, with improvements measured in seven of nine patients. VTA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) overlapped with the DRT in six patients and with the ML and\/or PT in six patients. All patients experienced side\u2010effects and QoL worsened during the first year after surgery, which improved again during long\u2010term follow\u2010up, although remaining below age\u2010related normal values. Most patients reported a positive effect of DBS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vim\/DRT\u2010DBS improved standing time in patients with severe OT. Observed side\u2010effects are possibly related to stimulation of the ML and PT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14035","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T04:58:43Z","timestamp":1712552323000},"page":"676-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Deep Brain Stimulation for Orthostatic Tremor: An Observational Study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7532-5320","authenticated-orcid":false,"given":"Wietske A.","family":"Babeliowsky","sequence":"first","affiliation":[{"name":"Neurology and Clinical Neurophysiology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Bot","sequence":"additional","affiliation":[{"name":"Neurosurgery Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter V.","family":"Potters","sequence":"additional","affiliation":[{"name":"Neurology and Clinical Neurophysiology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pepijn","family":"van den Munckhof","sequence":"additional","affiliation":[{"name":"Neurosurgery Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin R.","family":"Blok","sequence":"additional","affiliation":[{"name":"Neurology and Clinical Neurophysiology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-0784","authenticated-orcid":false,"given":"Rob M.A.","family":"de 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