{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:03:09Z","timestamp":1778313789762,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Phenotypes of CANVAS are increasingly diversified, including bradykinesia and dysautonomia, so that its primary differential diagnoses are multiple system atrophy\u2010cerebellar type (MSA\u2010c), and spinocerebellar ataxia type 3 (SCA3). This case series aims to highlight key molecular imaging findings in CANVAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Cases<\/jats:title><jats:p>We report a case series of six patients with CANVAS who underwent nuclear medicine examinations in our center and 13 patients from the literature. These include <jats:sup>18<\/jats:sup>F\u2010FDG brain positron emission tomography (PET), single photon emission computed tomography (SPECT) of dopamine transporter (DaT) activity, and <jats:sup>123<\/jats:sup>I\u2010MIBG cardiac scintigraphy of noradrenergic transmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In CANVAS, <jats:sup>18<\/jats:sup>F\u2010FDG brain PET mainly shows cerebellar hypometabolism, with preserved brainstem and striatum metabolism, contrasting with SCA3 and MSA\u2010c. Dopaminergic denervation on scintigraphy seems to be associated with clinical parkinsonism, ranging from normal to severely impaired DaT SPECT. Additionally, <jats:sup>123<\/jats:sup>I\u2010MIBG cardiac scintigraphy might show denervation in CANVAS, similar to SCA3, but not in most MSA\u2010c patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14041","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:54:45Z","timestamp":1712278485000},"page":"879-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Molecular Imaging in <scp>CANVAS<\/scp>: A Contribution for Differential Diagnosis?"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-309X","authenticated-orcid":false,"given":"Tatiana","family":"Horowitz","sequence":"first","affiliation":[{"name":"Nuclear Medicine Department Aix Marseille Univ, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Guedj","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department Aix Marseille Univ, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Eusebio","sequence":"additional","affiliation":[{"name":"Neurology and Movement Disorders Department APHM, Timone University Hospital  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Fluch\u00e8re","sequence":"additional","affiliation":[{"name":"Neurology and Movement Disorders Department APHM, Timone University Hospital  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Philippe","family":"Azulay","sequence":"additional","affiliation":[{"name":"Neurology and Movement Disorders Department APHM, Timone University Hospital  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilien","family":"Delmont","sequence":"additional","affiliation":[{"name":"Neurology Department, Reference Center for Neuromuscular Diseases and ALS, Public Assistance Hospitals of Marseille Timone University Hospital  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Neurology and Movement Disorders Department APHM, Timone University Hospital  Marseille France"},{"name":"CRMBM, CEMEREM, CNRS, Aix Marseille Univ  Marseille 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Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.14041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:38:04Z","timestamp":1760971084000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.14041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,4]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/mdc3.14041"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.14041","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,4]]},"assertion":[{"value":"2023-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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