{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:27:37Z","timestamp":1772825257948,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["FG\u20102700"],"award-info":[{"award-number":["FG\u20102700"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A 4\u2010item score based on \u22652 features out of orthostatic hypotension, overactive bladder, urinary retention and postural instability was previously shown to early distinguish the Parkinson\u2010variant of multiple system atrophy (MSA\u2010P)\u00a0from Parkinson's disease (PD) with 78% sensitivity and 86% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To replicate and improve the 4\u2010item MSA\u2010P score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied 161 patients with early parkinsonism [ie, \u22642\u2009years disease duration or no postural instability, aged 64 (57; 68) years, 44% females] and a diagnosis of clinically established MSA\u2010P (n\u2009=\u200938) or PD (n\u2009=\u2009123) after \u226524\u2009months follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 4\u2010item MSA\u2010P score had a 92% sensitivity and 78% specificity for a final MSA\u2010P diagnosis. By including dopaminergic responsiveness and postural deformities into a 6\u2010item score (range: 0\u20136), reaching \u22653 points at early disease identified MSA\u2010P patients with 89% sensitivity and 98% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 6\u2010item MSA\u2010P score is a cost\u2010effective tool to pinpoint individuals with early\u2010stage MSA\u2010P.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14048","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T01:58:41Z","timestamp":1714010321000},"page":"867-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early Screening for the Parkinson Variant of Multiple System Atrophy: A 6\u2010Item 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