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The performance of DaTSCAN is generally recommended in the follow\u2010up of patients with a clinically uncertain diagnosis, especially in those with a suspected essential tremor, drug\u2010induced parkinsonism, or vascular parkinsonism. However, there is a dearth of DaTSCAN findings regarding neurodegenerative parkinsonisms besides PD and atypical parkinsonisms. To date, a specific nigrostriatal dopamine uptake pattern that would help differentiate PD from the most frequent atypical parkinsonisms is yet to be described. This fact is further complicated by the possible visualization of abnormalities in the uptake pattern in patients with rarer neurodegenerative parkinsonisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to summarize the current literature regarding DaTSCAN findings in patients with rare neurodegenerative parkinsonisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PubMed database was systematically screened for studies in English or Spanish up to October 15, 2023, using search terms \u201cDaTSCAN\u201d, \u201cioflupane\u201d, \u201cDaT\u2010SPECT\u201d, \u201c123I\u2010FP\u2010CIT SPECT\u201d, \u201cdopamine transporter imaging\u201d, and \u201c[123I] FP\u2010CIT SPECT\u201d. Duplicated publications and studies regarding PD, atypical parkinsonisms, dystonia\u2010parkinsonism, essential tremor, and parkinsonism due to non\u2010degenerative causes were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The obtained results were reviewed and summarized, including DaTSCAN findings in fragile X\u2010associated tremor\/ataxia syndrome, prion diseases, Huntington's disease, spinocerebellar ataxia, hereditary spastic paraparesis, metabolic disorders, and other diseases (anti\u2010IgLON5 disease, ring chromosome 20 syndrome, chorea\u2010acanthocytosis, and neuronal ceroid lipofuscinosis).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review highlights the need to determine in the future the utility and cost\u2010effectiveness of DaTSCAN, both as a diagnostic and a prognostic tool, in patients with parkinsonian symptoms in rare neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14055","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T01:12:24Z","timestamp":1714612344000},"page":"613-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<scp>\n                      I\n                      <sup>123<\/sup>\n                      \u2010FP\u2010CIT\n                    <\/scp>\n                    (\n                    <scp>DaTSCAN<\/scp>\n                    )\n                    <scp>SPECT<\/scp>\n                    beyond the Most Common Causes of Parkinsonism: A Systematic 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